Thyroid hormone binding inhibition in critically ill patients--who is the inhibitor?

In 31 severely ill patients of our intensive care unit an increased thyroid hormone binding inhibition detected by quantitative measurement of the effect of ether extracts of patients' sera on thyroxine tracer binding to TBG was found. As free fatty acids in serum were diminished in these patie...

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Bibliographic Details
Published inExperimental and clinical endocrinology Vol. 95; no. 2; p. 267
Main Authors Schifferdecker, E, Hering, S, Böhm, B O, Förster, H, Althoff, P H, Schulz, F, Schöffling, K
Format Journal Article
LanguageEnglish
Published Germany 01.04.1990
Subjects
Acute Disease
Carrier Proteins - antagonists & inhibitors
Fatty Acids - analysis
Heparin - pharmacology
Humans
Membrane Proteins - antagonists & inhibitors
Thyroid Gland - drug effects
Thyroid Gland - metabolism
Thyroid Hormone-Binding Proteins
Thyroid Hormones
Thyroxine - analysis
Triiodothyronine - analysis
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Summary:In 31 severely ill patients of our intensive care unit an increased thyroid hormone binding inhibition detected by quantitative measurement of the effect of ether extracts of patients' sera on thyroxine tracer binding to TBG was found. As free fatty acids in serum were diminished in these patients, their postulated role as binding inhibitors in the "low T4 syndrome" of critically ill patients must be questioned. It cannot be excluded that THBI assays demonstrating this inhibition measure artefacts caused by heparine-induced in vitro lipolysis.
ISSN:0232-7384
DOI:10.1055/s-0029-1210963