Xenogeneic antibodies against hepatocyte plasma membranes suppress bile secretion in rats

The action of xenogeneic antibodies against rat hepatocyte plasma membranes which were injected into the portal vein in the dose of 40 mg of protein per kg of body mass on the bile secretion and on the ultrastructure of the liver were studied. It was shown that these antibodies suppressed the bile f...

Full description

Saved in:
Bibliographic Details
Published inExperimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie Vol. 45; no. 4; p. 211
Main Authors Makogon, N V, Alexeyeva, I N
Format Journal Article
LanguageEnglish
Published Germany 01.08.1993
Subjects
Animals
Antibodies, Heterophile - physiology
Bile - secretion
Cell Membrane - immunology
Liver - immunology
Rabbits
Rats
Rats, Wistar
Sodium - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Online AccessGet more information

Cover

More Information
Summary:The action of xenogeneic antibodies against rat hepatocyte plasma membranes which were injected into the portal vein in the dose of 40 mg of protein per kg of body mass on the bile secretion and on the ultrastructure of the liver were studied. It was shown that these antibodies suppressed the bile flow, the secretion of bile acids and cholesterol and decreased the bile salt-independent bile flow. The action of antibodies was accompanied by ultrastructural damage of sinusoidal and lateral plasma membranes of some hepatocytes and by a decrease in the Na+, K(+)-ATPase activity. It was concluded that the decrease of Na+, K(+)-ATPase activity in the plasma membranes was the most important mechanism responsible for a decrease in the bile flow.
ISSN:0940-2993
DOI:10.1016/S0940-2993(11)80391-X