An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

• Published in: Biosensors & bioelectronics Vol. 129; pp. 155 - 163
• Main Authors: Sinha, Anirban, Tai, Tse-Yu, Li, Kuang-Hsien, Gopinathan, Priya, Chung, Yi-Da, Sarangadharan, Indu, Ma, Hsi-Pin, Huang, Po-Chiun, Shiesh, Shu-Chu, Wang, Yu-Lin, Lee, Gwo-Bin
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 15.03.2019
• Subjects: Aptamers; Biomarkers; biosensors; C-reactive protein; Cardiovascular diseases; fibrinogen; Field-effect transistors; Microfluidics; natriuretic peptides; oligonucleotides; point-of-care systems; portable equipment; prototypes; risk; transistors; troponin I; CRP; cTnI; HEMT; TE buffer; EDL; AlGaN/GaN; NT-proBNP; SPR; ssDNA; SELEX; LOD; PBS; EMVs; EDTA; LCD; FET; PMMA; Field-effect transistors; Aptamers; Biomarkers; Cardiovascular diseases; CVDs; TCEP; Microfluidics; ELISA; PDMS

Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-...