An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples

Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-...

Full description

Saved in:

Bibliographic Details
Published in	Biosensors & bioelectronics Vol. 129; pp. 155 - 163
Main Authors	Sinha, Anirban, Tai, Tse-Yu, Li, Kuang-Hsien, Gopinathan, Priya, Chung, Yi-Da, Sarangadharan, Indu, Ma, Hsi-Pin, Huang, Po-Chiun, Shiesh, Shu-Chu, Wang, Yu-Lin, Lee, Gwo-Bin
Format	Journal Article
Language	English
Published	England Elsevier B.V 15.03.2019
Subjects	Aptamers Biomarkers biosensors C-reactive protein Cardiovascular diseases fibrinogen Field-effect transistors Microfluidics natriuretic peptides oligonucleotides point-of-care systems portable equipment prototypes risk transistors troponin I CRP cTnI HEMT TE buffer EDL AlGaN/GaN NT-proBNP SPR ssDNA SELEX LOD PBS EMVs EDTA LCD FET PMMA Field-effect transistors Aptamers Biomarkers Cardiovascular diseases CVDs TCEP Microfluidics ELISA PDMS
Online Access	Get full text

Cover

Loading…

Abstract	Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1–50 mg/L), NT-proBNP (50–10,000 pg/mL), cTnI (1–10,000 pg/mL), and fibrinogen (0.1–5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples. •An integrated microfluidic platform equipped with 1) immobilized aptamer probes and 2) field-effect transistor (FET)-based sensor arrays has been presented in this study.•Four biomarkers for cardiovascular diseases were rapidly (5 min) analyzed from clinical samples (~ 4 µL).•The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in patient serum.
AbstractList	Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1–50 mg/L), NT-proBNP (50–10,000 pg/mL), cTnI (1–10,000 pg/mL), and fibrinogen (0.1–5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples. Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1–50 mg/L), NT-proBNP (50–10,000 pg/mL), cTnI (1–10,000 pg/mL), and fibrinogen (0.1–5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples. •An integrated microfluidic platform equipped with 1) immobilized aptamer probes and 2) field-effect transistor (FET)-based sensor arrays has been presented in this study.•Four biomarkers for cardiovascular diseases were rapidly (5 min) analyzed from clinical samples (~ 4 µL).•The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in patient serum. Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1-50 mg/L), NT-proBNP (50-10,000 pg/mL), cTnI (1-10,000 pg/mL), and fibrinogen (0.1-5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples.Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the use of multiple biomarkers for proper risk assessment of CVDs. Herein four such CVDs biomarkers- C-reactive protein (CRP), N-terminal pro b-type natriuretic peptide (NT-proBNP), cardiac troponin I (cTnI), and fibrinogen- were rapidly (5 min) analyzed from clinical samples (~ 4 µL) on an integrated microfluidic platform equipped with 1) immobilized highly specific aptamer probes and 2) field-effect transistor (FET)-based sensor arrays. The calibration curve from the FET sensor arrays showed good agreement in the physiological concentration ranges for CRP (0.1-50 mg/L), NT-proBNP (50-10,000 pg/mL), cTnI (1-10,000 pg/mL), and fibrinogen (0.1-5 mg/mL). The developed prototype of this fully automated portable device requires minimal reagent and sample inputs and consequently shows great promise for next-generation point-of-care devices assaying multiple CVDs biomarkers in clinical samples.
Author	Chung, Yi-Da Sinha, Anirban Li, Kuang-Hsien Tai, Tse-Yu Shiesh, Shu-Chu Gopinathan, Priya Wang, Yu-Lin Sarangadharan, Indu Huang, Po-Chiun Ma, Hsi-Pin Lee, Gwo-Bin
Author_xml	– sequence: 1 givenname: Anirban surname: Sinha fullname: Sinha, Anirban organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan – sequence: 2 givenname: Tse-Yu surname: Tai fullname: Tai, Tse-Yu organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan – sequence: 3 givenname: Kuang-Hsien surname: Li fullname: Li, Kuang-Hsien organization: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan – sequence: 4 givenname: Priya surname: Gopinathan fullname: Gopinathan, Priya organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan – sequence: 5 givenname: Yi-Da surname: Chung fullname: Chung, Yi-Da organization: Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan – sequence: 6 givenname: Indu orcidid: 0000-0002-2889-3360 surname: Sarangadharan fullname: Sarangadharan, Indu organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan – sequence: 7 givenname: Hsi-Pin surname: Ma fullname: Ma, Hsi-Pin organization: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan – sequence: 8 givenname: Po-Chiun surname: Huang fullname: Huang, Po-Chiun organization: Department of Electrical Engineering, National Tsing Hua University, Hsinchu, Taiwan – sequence: 9 givenname: Shu-Chu surname: Shiesh fullname: Shiesh, Shu-Chu organization: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan – sequence: 10 givenname: Yu-Lin surname: Wang fullname: Wang, Yu-Lin email: ylwang@mx.nthu.edu.tw organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan – sequence: 11 givenname: Gwo-Bin surname: Lee fullname: Lee, Gwo-Bin email: gwobin@pme.nthu.edu.tw organization: Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu, Taiwan
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/30703568$$D View this record in MEDLINE/PubMed
BookMark	eNqNkctuFDEQRS0URCaBH2CBvGTTQ7k9_bDEJop4SZHYwNqqdleHGtzuYLuD5jv4YTyawIJFhGSpvDjXct1zIc7CEkiIlwq2ClT7Zr8deEnbGpTZgtoCqCdio_pOV7taN2diA6Zpq6Zt9bm4SGkPAJ0y8Eyca-hAN22_Eb-uguSQ6TZiplHO7OIy-ZVHdjIdUqZZ_uT8TU5MfqxomsjlKkcMiVNeokwUUhkYIx6SnMp1pFwYDrdyXn3mO0_SYRx5ucfkVo9Rll_PGL9TLIG4zNJ5DuzQy4RzwdNz8XRCn-jFw7wUX9-_-3L9sbr5_OHT9dVN5XRvctUZg6qcXaunWuuB-rppB40NDsNO78ay_djWk4FhAoRWKzQasSNoB1QERl-K16d37-LyY6WU7czJkfcYaFmTrVVvGt0B9P-BdmZX98VKQV89oOsw02jvIpdtD_ZP5wWoT0CpOqVI019EgT2KtXt7FGuPYi0oW8SWUP9PyHHGzEsoMtg_Hn17ilLp8p4p2uSYgqORYzFlx4Ufi_8GkPHBwA
CitedBy_id	crossref_primary_10_1016_j_saa_2024_124256 crossref_primary_10_1016_j_bioelechem_2022_108225 crossref_primary_10_1088_1361_6439_ac8a55 crossref_primary_10_3390_chemosensors11070416 crossref_primary_10_3390_mi14020325 crossref_primary_10_1002_elan_202200355 crossref_primary_10_1007_s11581_022_04780_4 crossref_primary_10_1016_j_bios_2022_114944 crossref_primary_10_1016_j_coelec_2021_100755 crossref_primary_10_1021_acssensors_4c00194 crossref_primary_10_1038_s41378_021_00245_2 crossref_primary_10_1038_s41378_021_00278_7 crossref_primary_10_1016_j_chphi_2023_100326 crossref_primary_10_1016_j_talanta_2024_127166 crossref_primary_10_1016_j_cca_2024_120079 crossref_primary_10_1002_cbic_202300560 crossref_primary_10_1021_acsnano_4c11857 crossref_primary_10_1109_TED_2024_3400926 crossref_primary_10_1063_5_0084758 crossref_primary_10_1186_s12951_023_01898_z crossref_primary_10_3389_fneur_2025_1488726 crossref_primary_10_3390_s24103008 crossref_primary_10_1002_slct_202101942 crossref_primary_10_1002_VIW_20240025 crossref_primary_10_1007_s00216_021_03658_0 crossref_primary_10_1007_s41664_023_00270_2 crossref_primary_10_3390_bios12050357 crossref_primary_10_3390_jpm12121942 crossref_primary_10_1021_acs_analchem_2c01133 crossref_primary_10_1002_EXP_20210027 crossref_primary_10_2139_ssrn_4145238 crossref_primary_10_1016_j_bios_2021_113114 crossref_primary_10_1016_j_cjac_2022_100190 crossref_primary_10_3390_s25030779 crossref_primary_10_3390_biomimetics7040175 crossref_primary_10_1515_revic_2024_0055 crossref_primary_10_29254_2077_4214_2023_2_169_269_277 crossref_primary_10_1007_s00216_021_03490_6 crossref_primary_10_1016_j_bios_2024_116229 crossref_primary_10_1016_j_bios_2023_115931 crossref_primary_10_1016_j_talanta_2024_126687 crossref_primary_10_1007_s11696_024_03304_w crossref_primary_10_1021_acs_analchem_4c04178 crossref_primary_10_1021_acs_analchem_9b04868 crossref_primary_10_3390_mi14040791 crossref_primary_10_1016_j_coelec_2021_100811 crossref_primary_10_3390_s22041620 crossref_primary_10_1016_j_talanta_2020_120868 crossref_primary_10_1016_j_cca_2020_12_034 crossref_primary_10_1109_JSEN_2024_3428312 crossref_primary_10_1007_s12598_024_02821_7 crossref_primary_10_1016_j_cca_2024_117841 crossref_primary_10_1021_acsanm_3c03705 crossref_primary_10_1007_s00604_022_05171_2 crossref_primary_10_1016_S1872_2040_20_60040_8 crossref_primary_10_1002_slct_202203155 crossref_primary_10_1039_C9LC00115H crossref_primary_10_1016_j_cpcardiol_2023_102180 crossref_primary_10_1088_1361_6528_acf3f0 crossref_primary_10_3390_mi13030425 crossref_primary_10_1039_D4LC00859F crossref_primary_10_1186_s12951_021_01224_5 crossref_primary_10_1007_s00216_021_03674_0 crossref_primary_10_1142_S1793292024300056 crossref_primary_10_1149_2_0072003JES crossref_primary_10_1039_D1RA00589H crossref_primary_10_3390_bios12050334 crossref_primary_10_1021_acsabm_0c01271 crossref_primary_10_1080_10408347_2024_2356842 crossref_primary_10_3390_mi12040347 crossref_primary_10_1016_j_jpba_2020_113777 crossref_primary_10_1021_acs_analchem_4c01046 crossref_primary_10_1016_j_bios_2020_112621 crossref_primary_10_3390_bios12111023 crossref_primary_10_3390_mi12060691 crossref_primary_10_1016_j_talanta_2020_121070 crossref_primary_10_1016_j_talanta_2023_124280 crossref_primary_10_1021_acs_analchem_1c04476
Cites_doi	10.1021/acssensors.5b00318 10.1007/s11011-017-9967-6 10.1002/jcla.20366 10.1021/ac071262n 10.1002/jps.20821 10.1038/s41598-017-05426-6 10.1038/nrm4041 10.1016/j.amjcard.2012.11.060 10.1093/clinchem/45.9.1628 10.1093/nar/gks1093 10.2147/IJN.S89307 10.1039/c2lc21204h 10.1021/ja061620o 10.1038/srep07352 10.1016/j.jacc.2012.03.074 10.1063/1.4995257 10.3390/chemosensors4040020 10.1016/j.bios.2017.09.018 10.1016/j.bios.2012.09.066 10.1021/ac101716p 10.1016/j.bios.2018.09.040 10.1371/journal.pone.0119207 10.1016/j.bios.2009.12.029 10.1016/j.ehj.2014.11.005 10.1136/heart.89.2.150 10.3390/s17092116 10.1146/annurev-pharmtox-010716-104558 10.1016/j.snb.2005.02.019 10.2174/1568026611313020002 10.32607/20758251-2013-5-4-34-43 10.1007/s00216-001-1189-3 10.1097/TA.0000000000000546 10.1007/978-1-62703-339-8_14 10.1136/jcp.2003.015420 10.1063/1.5011151 10.1088/0960-1317/3/4/002 10.1063/1.5000247 10.1039/c2an35042d 10.1557/opl.2015.131 10.1088/0953-8984/16/29/R02 10.1172/JCI200318921 10.1016/j.bios.2012.02.024 10.1021/acsnano.5b01211 10.3390/bios4040340 10.1063/1.2772192 10.1038/nrd3141 10.1161/CIRCULATIONAHA.104.482570
ContentType	Journal Article
Copyright	2019 Elsevier B.V. Copyright © 2019 Elsevier B.V. All rights reserved.
Copyright_xml	– notice: 2019 Elsevier B.V. – notice: Copyright © 2019 Elsevier B.V. All rights reserved.
DBID	AAYXX CITATION NPM 7X8 7S9 L.6
DOI	10.1016/j.bios.2019.01.001
DatabaseName	CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitle	CrossRef PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic
DatabaseTitleList	AGRICOLA PubMed MEDLINE - Academic
Database_xml	– sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Engineering Biology
EISSN	1873-4235
EndPage	163
ExternalDocumentID	30703568 10_1016_j_bios_2019_01_001 S0956566319300053
Genre	Journal Article
GroupedDBID	--- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 23N 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM 9JN AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AARLI AAXUO ABGSF ABJNI ABMAC ABUDA ABYKQ ACDAQ ACGFS ACRLP ADBBV ADECG ADEZE ADTZH ADUVX AEBSH AECPX AEHWI AEKER AENEX AFKWA AFTJW AFXIZ AFZHZ AGHFR AGUBO AGYEJ AHJVU AIEXJ AIKHN AITUG AJOXV AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BJAXD BKOJK BLXMC CS3 DOVZS DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FLBIZ FNPLU FYGXN G-Q GBLVA IHE J1W JJJVA KOM LX3 M36 M41 MO0 N9A O-L O9- OAUVE OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPC SPCBC SSK SST SSU SSZ T5K TN5 XPP Y6R YK3 ZMT ~G- ~KM .HR 53G AAHBH AAQXK AATTM AAXKI AAYWO AAYXX ABFNM ABWVN ABXDB ACNNM ACRPL ACVFH ADCNI ADMUD ADNMO AEIPS AEUPX AFFNX AFJKZ AFPUW AGCQF AGQPQ AGRDE AGRNS AHHHB AIGII AIIUN AJQLL AKBMS AKRWK AKYEP ANKPU APXCP ASPBG AVWKF AZFZN BNPGV CITATION FEDTE FGOYB G-2 HLW HMU HVGLF HZ~ R2- SBG SCB SCH SEW SSH WUQ NPM 7X8 7S9 L.6
ID	FETCH-LOGICAL-c389t-799a19a1463f233be8256b3a5abb434d095d62f90bf0a0631a93aa7e06ba1e093
IEDL.DBID	.~1
ISSN	0956-5663 1873-4235
IngestDate	Fri Jul 11 02:29:43 EDT 2025 Fri Jul 11 03:03:21 EDT 2025 Thu Apr 03 07:10:43 EDT 2025 Tue Jul 01 01:42:45 EDT 2025 Thu Apr 24 22:57:29 EDT 2025 Fri Feb 23 02:29:50 EST 2024
IsPeerReviewed	true
IsScholarly	true
Keywords	CRP cTnI HEMT TE buffer EDL AlGaN/GaN NT-proBNP SPR ssDNA SELEX LOD PBS EMVs EDTA LCD FET PMMA Field-effect transistors Aptamers Biomarkers Cardiovascular diseases CVDs TCEP Microfluidics ELISA PDMS
Language	English
License	Copyright © 2019 Elsevier B.V. All rights reserved.
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c389t-799a19a1463f233be8256b3a5abb434d095d62f90bf0a0631a93aa7e06ba1e093
Notes	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
ORCID	0000-0002-2889-3360
PMID	30703568
PQID	2179428016
PQPubID	23479
PageCount	9
ParticipantIDs	proquest_miscellaneous_2189537008 proquest_miscellaneous_2179428016 pubmed_primary_30703568 crossref_primary_10_1016_j_bios_2019_01_001 crossref_citationtrail_10_1016_j_bios_2019_01_001 elsevier_sciencedirect_doi_10_1016_j_bios_2019_01_001
ProviderPackageCode	CITATION AAYXX
PublicationCentury	2000
PublicationDate	2019-03-15
PublicationDateYYYYMMDD	2019-03-15
PublicationDate_xml	– month: 03 year: 2019 text: 2019-03-15 day: 15
PublicationDecade	2010
PublicationPlace	England
PublicationPlace_xml	– name: England
PublicationTitle	Biosensors & bioelectronics
PublicationTitleAlternate	Biosens Bioelectron
PublicationYear	2019
Publisher	Elsevier B.V
Publisher_xml	– name: Elsevier B.V
References	Nafee, Taetz, Schneider, Schaefer, Lehr, Nimjee, White, Becker, Sullenger (bib25) 2017; 57 Stang, Mitchell (bib42) 2013 Dupont, Thuesen, Bøtkjær, Behrens, Dam, Sørensen, Pedersen, Ploug, Jensen, Andreasen (bib8) 2015; 10 Lakhin, Tarantul, Gening (bib22) 2013; 5 Thompson, Craig (bib43) 2011 Gravesen, Branebjerg, Jensen (bib11) 1993; 3 Huang, Lin, Shiesh, Lee (bib14) 2012; 35 Poon, Lyng, Knief, Howe, Meade, Curtin, Byrne, Vaughan (bib32) 2012; 137 Tsai, Hsu, Chiu, Bor Fuh (bib45) 2007; 79 Kao, Chen, Chu, Chang, Shiesh, Wang, Lee (bib18) 2017; 11 Tsumoto, Ejima, Senczuk, Kita, Arakawa (bib46) 2007; 96 Formaneck, Ma, Cui (bib10) 2006; 128 Pearton, Kang, Kim, Ren, Gila, Abernathy, Lin, Chu (bib30) 2004; 16 Chu, Sarangadharan, Regmi, Chen, Hsu, Chang, Lee, Chyi, Chen, Shiesh, Lee, Wang (bib5) 2017; 7 Toda, Sato, Hara, Hijiya, Kaneko, Okada, Takatsu, Fujiwara, Iwasaki (bib44) 2010; 24 Huang, Lin, Shiesh, Lee (bib15) 2010; 25 Sinha, Gopinathan, Chung, Da, Lin, Li, Ma, Huang, Shiesh, Lee (bib38) 2018; 122 Cheng, Tsai, Lin, Chen, Hsu, Hong, Liu (bib3) 2006; 113 Nayeli, Stefan, Volker, Oliver (bib26) 2015; 1763 O’Sullivan (bib28) 2002; 372 Panagopoulou, Deftereos, Kossyvakis, Raisakis, Giannopoulos, Bouras, Pyrgakis, Cleman (bib29) 2013; 13 Shrivastava, Singh, Raizada, Singh (bib37) 2015; 67 Skalny, Klimenko, Turna, Budanova, Baskakov, Savostina, Mazilina, Deyev, Skalnaya, Tinkov (bib39) 2017; 32 Celermajer, Chow, Marijon, Anstey, Woo (bib2) 2012; 60 Pepys, Hirschfield (bib31) 2003; 111 Kim, Kim, Kim, Huh, Ah, Kim, Hong, Park, Song, Song, Sung (bib21) 2010; 82 Regmi, Sarangadharan, Chen, Hsu, Lee, Chyi, Shiesh, Lee, Wang (bib33) 2017; 111 Ndrepepa, Braun, King, Fusaro, Keta, Cassese, Tada, Schömig, Kastrati (bib27) 2013; 111 Schlimp, Khadem, Klotz, Solomon, Hochleitner, Ponschab, Redl, Schöchl (bib35) 2015; 78 Mozaffarian, Benjamin, Go, Arnett, Blaha, Cushman, Das, Ferranti, De, Després, Fullerton, Howard, Huffman, Isasi, Jiménez, Judd, Kissela, Lichtman, Lisabeth, Liu, MacKey, Magid, McGuire, Mohler, Moy, Muntner, Mussolino, Nasir, Neumar, Nichol, Palaniappan, Pandey, Reeves, Rodriguez, Rosamond, Sorlie, Stein, Towfighi, Turan, Virani, Woo, Yeh, Turner (bib24) 2016; 133 Bay, Kirk, Parner, Hassager, Nielsen (bib1) 2003 Smestad, James Maher (bib40) 2013; 41 Vasan (bib47) 2006; 113 Jayasena (bib16) 1999; 45 Yang, Carey, Ren, Wang, Good, Jang, Mastro, Pearton (bib49) 2017; 111 Kim, Rim, Chen, Cao, Nakatsuka, Hinton, Zhao, Andrews, Yang, Weiss (bib20) 2015; 9 Sarangadharan, Regmi, Chen, Hsu, Chen, chi, Chang, Lee, Chyi, Shiesh, Lee, Wang (bib34) 2018; 100 Chin, Linder, Sia (bib4) 2012; 12 Zhang, Bao, Draz, Lu, Liu, Han (bib50) 2015; 10 De Moraes, Kubota (bib6) 2016; 4 Fakanya, Tothill (bib9) 2014; 4 World Health Organization (bib48) 2016 Lee, Dak, Lee, Park, Choi, Alam, Kim (bib23) 2015; 4 Song, Nimse, Sonawane, Warkad, Kim (bib41) 2017; 17 Keefe, Pai, Ellington (bib19) 2010; 9 Huang, Lee, Chyi, Cheng, Hsu, Hsu, Hsu, Huang, Sun, Chen, Li, Andrew Yeh, Yao, Ren, Wang (bib13) 2013; 41 Kang, Wang, Lele, Tseng, Ren, Pearton, Johnson, Rajagopal, Roberts, Piner, Linthicum (bib17) 2007; 91 Duncombe, Tentori, Herr (bib7) 2015; 16 Han, Li, Peng, Othman, Leblanc (bib12) 2016; 1 Sharma, Jackson, Makan (bib36) 2004; 57 Duncombe (10.1016/j.bios.2019.01.001_bib7) 2015; 16 Stang (10.1016/j.bios.2019.01.001_bib42) 2013 Regmi (10.1016/j.bios.2019.01.001_bib33) 2017; 111 Huang (10.1016/j.bios.2019.01.001_bib15) 2010; 25 Formaneck (10.1016/j.bios.2019.01.001_bib10) 2006; 128 Dupont (10.1016/j.bios.2019.01.001_bib8) 2015; 10 Sarangadharan (10.1016/j.bios.2019.01.001_bib34) 2018; 100 World Health Organization (10.1016/j.bios.2019.01.001_bib48) 2016 Kim (10.1016/j.bios.2019.01.001_bib21) 2010; 82 Lee (10.1016/j.bios.2019.01.001_bib23) 2015; 4 Fakanya (10.1016/j.bios.2019.01.001_bib9) 2014; 4 Nayeli (10.1016/j.bios.2019.01.001_bib26) 2015; 1763 Gravesen (10.1016/j.bios.2019.01.001_bib11) 1993; 3 Kao (10.1016/j.bios.2019.01.001_bib18) 2017; 11 Huang (10.1016/j.bios.2019.01.001_bib13) 2013; 41 Poon (10.1016/j.bios.2019.01.001_bib32) 2012; 137 Chu (10.1016/j.bios.2019.01.001_bib5) 2017; 7 Han (10.1016/j.bios.2019.01.001_bib12) 2016; 1 Huang (10.1016/j.bios.2019.01.001_bib14) 2012; 35 Kim (10.1016/j.bios.2019.01.001_bib20) 2015; 9 Lakhin (10.1016/j.bios.2019.01.001_bib22) 2013; 5 Cheng (10.1016/j.bios.2019.01.001_bib3) 2006; 113 Pearton (10.1016/j.bios.2019.01.001_bib30) 2004; 16 Mozaffarian (10.1016/j.bios.2019.01.001_bib24) 2016; 133 Schlimp (10.1016/j.bios.2019.01.001_bib35) 2015; 78 De Moraes (10.1016/j.bios.2019.01.001_bib6) 2016; 4 Ndrepepa (10.1016/j.bios.2019.01.001_bib27) 2013; 111 Thompson (10.1016/j.bios.2019.01.001_bib43) 2011 Song (10.1016/j.bios.2019.01.001_bib41) 2017; 17 Jayasena (10.1016/j.bios.2019.01.001_bib16) 1999; 45 Shrivastava (10.1016/j.bios.2019.01.001_bib37) 2015; 67 Sinha (10.1016/j.bios.2019.01.001_bib38) 2018; 122 Sharma (10.1016/j.bios.2019.01.001_bib36) 2004; 57 Skalny (10.1016/j.bios.2019.01.001_bib39) 2017; 32 Celermajer (10.1016/j.bios.2019.01.001_bib2) 2012; 60 Nafee (10.1016/j.bios.2019.01.001_bib25) 2017; 57 Panagopoulou (10.1016/j.bios.2019.01.001_bib29) 2013; 13 Pepys (10.1016/j.bios.2019.01.001_bib31) 2003; 111 Smestad (10.1016/j.bios.2019.01.001_bib40) 2013; 41 Yang (10.1016/j.bios.2019.01.001_bib49) 2017; 111 Kang (10.1016/j.bios.2019.01.001_bib17) 2007; 91 Chin (10.1016/j.bios.2019.01.001_bib4) 2012; 12 O’Sullivan (10.1016/j.bios.2019.01.001_bib28) 2002; 372 Toda (10.1016/j.bios.2019.01.001_bib44) 2010; 24 Keefe (10.1016/j.bios.2019.01.001_bib19) 2010; 9 Vasan (10.1016/j.bios.2019.01.001_bib47) 2006; 113 Tsai (10.1016/j.bios.2019.01.001_bib45) 2007; 79 Tsumoto (10.1016/j.bios.2019.01.001_bib46) 2007; 96 Bay (10.1016/j.bios.2019.01.001_bib1) 2003 Zhang (10.1016/j.bios.2019.01.001_bib50) 2015; 10
References_xml	– volume: 137 start-page: 1807 year: 2012 ident: bib32 article-title: Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy publication-title: Analyst – volume: 82 start-page: 9686 year: 2010 end-page: 9693 ident: bib21 article-title: Response to cardiac markers in human serum analyzed by guided-mode resonance biosensor publication-title: Anal. Chem. – volume: 96 start-page: 1677 year: 2007 end-page: 1690 ident: bib46 article-title: Effects of salts on protein–surface interactions: applications for column chromatography publication-title: J. Pharm. Sci. – volume: 60 start-page: 1207 year: 2012 end-page: 1216 ident: bib2 article-title: Cardiovascular disease in the developing world publication-title: J. Am. Coll. Cardiol. – volume: 78 start-page: 830 year: 2015 end-page: 836 ident: bib35 article-title: Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer publication-title: J. Trauma Acute Care Surg. – volume: 10 start-page: 1 year: 2015 end-page: 22 ident: bib8 article-title: Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites publication-title: PLoS One – volume: 100 start-page: 282 year: 2018 end-page: 289 ident: bib34 article-title: High sensitivity cardiac troponin I detection in physiological environment using AlGaN/GaN high electron mobility transistor (HEMT) biosensors publication-title: Biosens. Bioelectron. – volume: 111 start-page: 1805 year: 2003 end-page: 1812 ident: bib31 article-title: C-reactive protein: a critical update publication-title: J. Clin. Invest. – year: 2011 ident: bib43 article-title: Coronary Care Manual, Coronary Care Manual – volume: 17 start-page: 2116 year: 2017 ident: bib41 article-title: Ultra-sensitive NT-proBNP quantification for early detection of risk factors leading to heart failure publication-title: Sensors – volume: 67 start-page: 89 year: 2015 end-page: 97 ident: bib37 article-title: C-reactive protein, inflammation and coronary heart disease publication-title: Egypt. Heart J. – volume: 10 start-page: 6161 year: 2015 end-page: 6173 ident: bib50 article-title: Rapid and quantitative detection of C-reactive protein based on quantum dots and immunofiltration assay publication-title: Int. J. Nanomed. – volume: 5 start-page: 34 year: 2013 end-page: 43 ident: bib22 article-title: Aptamers: problems, solutions and prospects publication-title: Acta Nat. – volume: 4 start-page: 20 year: 2016 ident: bib6 article-title: Recent trends in field-effect transistors-based immunosensors publication-title: Chemosensors – volume: 111 start-page: 202104 year: 2017 ident: bib49 article-title: Rapid detection of cardiac troponin I using antibody-immobilized gate-pulsed AlGaN/GaN high electron mobility transistor structures publication-title: Appl. Phys. Lett. – volume: 111 start-page: 082106 year: 2017 ident: bib33 article-title: Direct detection of fibrinogen in human plasma using electric-double-layer gated AlGaN/GaN high electron mobility transistors publication-title: Appl. Phys. Lett. – volume: 113 start-page: 29 year: 2006 end-page: 35 ident: bib3 article-title: Characteristics of a Pd–oxide–In publication-title: Sens. Actuators B Chem. – volume: 41 start-page: 1329 year: 2013 end-page: 1342 ident: bib40 article-title: Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis publication-title: Nucleic Acids Res. – volume: 24 start-page: 12 year: 2010 end-page: 16 ident: bib44 article-title: Correlates of NT-proBNP concentration in patients with essential hypertension in absence of congestive heart failure publication-title: J. Clin. Lab. Anal. – volume: 372 start-page: 44 year: 2002 end-page: 48 ident: bib28 article-title: Aptasensors – the future of biosensing? publication-title: Anal. Bioanal. Chem. – volume: 57 start-page: 1025 year: 2004 end-page: 1026 ident: bib36 article-title: Cardiac troponins publication-title: J. Clin. Pathol. – start-page: 181 year: 2013 end-page: 192 ident: bib42 article-title: Fibrinogen publication-title: Methods Mol. Biol. – volume: 12 start-page: 2118 year: 2012 ident: bib4 article-title: Commercialization of microfluidic point-of-care diagnostic devices publication-title: Lab Chip – volume: 11 start-page: 044105 year: 2017 ident: bib18 article-title: Detection of C-reactive protein on an integrated microfluidic system by utilizing field-effect transistors and aptamers publication-title: Biomicrofluidics – volume: 41 start-page: 717 year: 2013 end-page: 722 ident: bib13 article-title: AlGaN/GaN high electron mobility transistors for protein–peptide binding affinity study publication-title: Biosens. Bioelectron. – volume: 9 start-page: 537 year: 2010 end-page: 550 ident: bib19 article-title: Aptamers as therapeutics publication-title: Nat. Rev. Drug Discov. – volume: 32 start-page: 779 year: 2017 end-page: 788 ident: bib39 article-title: Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke publication-title: Metab. Brain Dis. – volume: 7 start-page: 5256 year: 2017 ident: bib5 article-title: Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum publication-title: Sci. Rep. – volume: 111 start-page: 804 year: 2013 end-page: 810 ident: bib27 article-title: Relation of fibrinogen level with cardiovascular events in patients with coronary artery disease publication-title: Am. J. Cardiol. – volume: 91 start-page: 112106 year: 2007 ident: bib17 article-title: Prostate specific antigen detection using AlGaN∕GaN high electron mobility transistors publication-title: Appl. Phys. Lett. – volume: 57 start-page: 61 year: 2017 end-page: 79 ident: bib25 article-title: Aptamers as therapeutics publication-title: Annu. Rev. Pharmacol. Toxicol. – volume: 133 start-page: e38 year: 2016 end-page: e48 ident: bib24 article-title: Heart disease and stroke statistics-2016 update a report from the American Heart Association publication-title: Circulation – volume: 1 start-page: 106 year: 2016 end-page: 114 ident: bib12 article-title: Recent development of cardiac troponin I setection publication-title: ACS Sens. – volume: 9 start-page: 4572 year: 2015 end-page: 4582 ident: bib20 article-title: Fabrication of high-performance ultrathin In publication-title: ACS Nano – year: 2016 ident: bib48 publication-title: Hearts: Technical Package for Cardiovascular Disease Management in Primary Health Care – volume: 16 start-page: R961 year: 2004 end-page: R994 ident: bib30 article-title: GaN-based diodes and transistors for chemical, gas, biological and pressure sensing publication-title: J. Phys. Condens. Matter – volume: 3 start-page: 168 year: 1993 end-page: 182 ident: bib11 article-title: Microfluidics – a review publication-title: J. Micromech. Microeng. – volume: 122 start-page: 104 year: 2018 end-page: 112 ident: bib38 article-title: An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers publication-title: Biosens. Bioelectron. – volume: 16 start-page: 554 year: 2015 end-page: 567 ident: bib7 article-title: Microfluidics: reframing biological enquiry publication-title: Nat. Rev. Mol. Cell Biol. – volume: 35 start-page: 50 year: 2012 end-page: 55 ident: bib14 article-title: An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers publication-title: Biosens. Bioelectron. – volume: 4 start-page: 340 year: 2014 end-page: 357 ident: bib9 article-title: Detection of the inflammation biomarker C-reactive protein in serum samples: towards an optimal biosensor formula publication-title: Biosensors – year: 2003 ident: bib1 article-title: NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function publication-title: Heart – volume: 128 start-page: 9506 year: 2006 end-page: 9517 ident: bib10 article-title: Effects of temperature and salt concentration on the structural stability of human lymphotactin: insights from molecular simulations publication-title: J. Am. Chem. Soc. – volume: 45 start-page: 1628 year: 1999 end-page: 1650 ident: bib16 article-title: Aptamers: an emerging class of molecules that rival antibodies in diagnostics publication-title: Clin. Chem. – volume: 4 start-page: 7352 year: 2015 ident: bib23 article-title: Two-dimensional layered MoS publication-title: Sci. Rep. – volume: 1763 year: 2015 ident: bib26 article-title: Sips adsorption model for DNA sensing with AlGaN/GaN high electron mobility transistors publication-title: MRS Proc. – volume: 113 start-page: 2335 year: 2006 end-page: 2362 ident: bib47 article-title: Biomarkers of cardiovascular disease: molecular basis and practical considerations publication-title: Circulation – volume: 13 start-page: 82 year: 2013 end-page: 94 ident: bib29 article-title: NTproBNP: an important biomarker in vardiac diseases publication-title: Curr. Top. Med. Chem. – volume: 25 start-page: 1761 year: 2010 end-page: 1766 ident: bib15 article-title: Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX) publication-title: Biosens. Bioelectron. – volume: 79 start-page: 8416 year: 2007 end-page: 8419 ident: bib45 article-title: Detection of C-reactive protein based on immunoassay using antibody-conjugated magnetic nanoparticles publication-title: Anal. Chem. – volume: 1 start-page: 106 year: 2016 ident: 10.1016/j.bios.2019.01.001_bib12 article-title: Recent development of cardiac troponin I setection publication-title: ACS Sens. doi: 10.1021/acssensors.5b00318 – volume: 32 start-page: 779 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib39 article-title: Serum trace elements are associated with hemostasis, lipid spectrum and inflammatory markers in men suffering from acute ischemic stroke publication-title: Metab. Brain Dis. doi: 10.1007/s11011-017-9967-6 – volume: 24 start-page: 12 year: 2010 ident: 10.1016/j.bios.2019.01.001_bib44 article-title: Correlates of NT-proBNP concentration in patients with essential hypertension in absence of congestive heart failure publication-title: J. Clin. Lab. Anal. doi: 10.1002/jcla.20366 – volume: 79 start-page: 8416 year: 2007 ident: 10.1016/j.bios.2019.01.001_bib45 article-title: Detection of C-reactive protein based on immunoassay using antibody-conjugated magnetic nanoparticles publication-title: Anal. Chem. doi: 10.1021/ac071262n – volume: 96 start-page: 1677 year: 2007 ident: 10.1016/j.bios.2019.01.001_bib46 article-title: Effects of salts on protein–surface interactions: applications for column chromatography publication-title: J. Pharm. Sci. doi: 10.1002/jps.20821 – volume: 7 start-page: 5256 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib5 article-title: Beyond the Debye length in high ionic strength solution: direct protein detection with field-effect transistors (FETs) in human serum publication-title: Sci. Rep. doi: 10.1038/s41598-017-05426-6 – volume: 16 start-page: 554 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib7 article-title: Microfluidics: reframing biological enquiry publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm4041 – volume: 111 start-page: 804 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib27 article-title: Relation of fibrinogen level with cardiovascular events in patients with coronary artery disease publication-title: Am. J. Cardiol. doi: 10.1016/j.amjcard.2012.11.060 – volume: 45 start-page: 1628 year: 1999 ident: 10.1016/j.bios.2019.01.001_bib16 article-title: Aptamers: an emerging class of molecules that rival antibodies in diagnostics publication-title: Clin. Chem. doi: 10.1093/clinchem/45.9.1628 – volume: 41 start-page: 1329 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib40 article-title: Ion-dependent conformational switching by a DNA aptamer that induces remyelination in a mouse model of multiple sclerosis publication-title: Nucleic Acids Res. doi: 10.1093/nar/gks1093 – volume: 10 start-page: 6161 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib50 article-title: Rapid and quantitative detection of C-reactive protein based on quantum dots and immunofiltration assay publication-title: Int. J. Nanomed. doi: 10.2147/IJN.S89307 – volume: 12 start-page: 2118 year: 2012 ident: 10.1016/j.bios.2019.01.001_bib4 article-title: Commercialization of microfluidic point-of-care diagnostic devices publication-title: Lab Chip doi: 10.1039/c2lc21204h – volume: 128 start-page: 9506 year: 2006 ident: 10.1016/j.bios.2019.01.001_bib10 article-title: Effects of temperature and salt concentration on the structural stability of human lymphotactin: insights from molecular simulations publication-title: J. Am. Chem. Soc. doi: 10.1021/ja061620o – volume: 4 start-page: 7352 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib23 article-title: Two-dimensional layered MoS2 biosensors enable highly sensitive detection of biomolecules publication-title: Sci. Rep. doi: 10.1038/srep07352 – volume: 60 start-page: 1207 year: 2012 ident: 10.1016/j.bios.2019.01.001_bib2 article-title: Cardiovascular disease in the developing world publication-title: J. Am. Coll. Cardiol. doi: 10.1016/j.jacc.2012.03.074 – volume: 11 start-page: 044105 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib18 article-title: Detection of C-reactive protein on an integrated microfluidic system by utilizing field-effect transistors and aptamers publication-title: Biomicrofluidics doi: 10.1063/1.4995257 – volume: 4 start-page: 20 year: 2016 ident: 10.1016/j.bios.2019.01.001_bib6 article-title: Recent trends in field-effect transistors-based immunosensors publication-title: Chemosensors doi: 10.3390/chemosensors4040020 – volume: 100 start-page: 282 year: 2018 ident: 10.1016/j.bios.2019.01.001_bib34 article-title: High sensitivity cardiac troponin I detection in physiological environment using AlGaN/GaN high electron mobility transistor (HEMT) biosensors publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2017.09.018 – volume: 41 start-page: 717 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib13 article-title: AlGaN/GaN high electron mobility transistors for protein–peptide binding affinity study publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2012.09.066 – volume: 82 start-page: 9686 year: 2010 ident: 10.1016/j.bios.2019.01.001_bib21 article-title: Response to cardiac markers in human serum analyzed by guided-mode resonance biosensor publication-title: Anal. Chem. doi: 10.1021/ac101716p – volume: 122 start-page: 104 year: 2018 ident: 10.1016/j.bios.2019.01.001_bib38 article-title: An integrated microfluidic platform to perform uninterrupted SELEX cycles to screen affinity reagents specific to cardiovascular biomarkers publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2018.09.040 – volume: 10 start-page: 1 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib8 article-title: Protein-binding RNA aptamers affect molecular interactions distantly from their binding sites publication-title: PLoS One doi: 10.1371/journal.pone.0119207 – volume: 25 start-page: 1761 year: 2010 ident: 10.1016/j.bios.2019.01.001_bib15 article-title: Integrated microfluidic system for rapid screening of CRP aptamers utilizing systematic evolution of ligands by exponential enrichment (SELEX) publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2009.12.029 – volume: 67 start-page: 89 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib37 article-title: C-reactive protein, inflammation and coronary heart disease publication-title: Egypt. Heart J. doi: 10.1016/j.ehj.2014.11.005 – year: 2016 ident: 10.1016/j.bios.2019.01.001_bib48 – year: 2003 ident: 10.1016/j.bios.2019.01.001_bib1 article-title: NT-proBNP: a new diagnostic screening tool to differentiate between patients with normal and reduced left ventricular systolic function publication-title: Heart doi: 10.1136/heart.89.2.150 – volume: 17 start-page: 2116 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib41 article-title: Ultra-sensitive NT-proBNP quantification for early detection of risk factors leading to heart failure publication-title: Sensors doi: 10.3390/s17092116 – volume: 57 start-page: 61 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib25 article-title: Aptamers as therapeutics publication-title: Annu. Rev. Pharmacol. Toxicol. doi: 10.1146/annurev-pharmtox-010716-104558 – volume: 113 start-page: 29 year: 2006 ident: 10.1016/j.bios.2019.01.001_bib3 article-title: Characteristics of a Pd–oxide–In0.49Ga0.51P high electron mobility transistor (HEMT)-based hydrogen sensor publication-title: Sens. Actuators B Chem. doi: 10.1016/j.snb.2005.02.019 – volume: 13 start-page: 82 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib29 article-title: NTproBNP: an important biomarker in vardiac diseases publication-title: Curr. Top. Med. Chem. doi: 10.2174/1568026611313020002 – volume: 133 start-page: e38 year: 2016 ident: 10.1016/j.bios.2019.01.001_bib24 article-title: Heart disease and stroke statistics-2016 update a report from the American Heart Association publication-title: Circulation – volume: 5 start-page: 34 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib22 article-title: Aptamers: problems, solutions and prospects publication-title: Acta Nat. doi: 10.32607/20758251-2013-5-4-34-43 – volume: 372 start-page: 44 year: 2002 ident: 10.1016/j.bios.2019.01.001_bib28 article-title: Aptasensors – the future of biosensing? publication-title: Anal. Bioanal. Chem. doi: 10.1007/s00216-001-1189-3 – volume: 78 start-page: 830 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib35 article-title: Rapid measurement of fibrinogen concentration in whole blood using a steel ball coagulometer publication-title: J. Trauma Acute Care Surg. doi: 10.1097/TA.0000000000000546 – start-page: 181 year: 2013 ident: 10.1016/j.bios.2019.01.001_bib42 article-title: Fibrinogen publication-title: Methods Mol. Biol. doi: 10.1007/978-1-62703-339-8_14 – volume: 57 start-page: 1025 year: 2004 ident: 10.1016/j.bios.2019.01.001_bib36 article-title: Cardiac troponins publication-title: J. Clin. Pathol. doi: 10.1136/jcp.2003.015420 – volume: 111 start-page: 202104 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib49 article-title: Rapid detection of cardiac troponin I using antibody-immobilized gate-pulsed AlGaN/GaN high electron mobility transistor structures publication-title: Appl. Phys. Lett. doi: 10.1063/1.5011151 – year: 2011 ident: 10.1016/j.bios.2019.01.001_bib43 – volume: 3 start-page: 168 year: 1993 ident: 10.1016/j.bios.2019.01.001_bib11 article-title: Microfluidics – a review publication-title: J. Micromech. Microeng. doi: 10.1088/0960-1317/3/4/002 – volume: 111 start-page: 082106 year: 2017 ident: 10.1016/j.bios.2019.01.001_bib33 article-title: Direct detection of fibrinogen in human plasma using electric-double-layer gated AlGaN/GaN high electron mobility transistors publication-title: Appl. Phys. Lett. doi: 10.1063/1.5000247 – volume: 137 start-page: 1807 year: 2012 ident: 10.1016/j.bios.2019.01.001_bib32 article-title: Quantitative reagent-free detection of fibrinogen levels in human blood plasma using Raman spectroscopy publication-title: Analyst doi: 10.1039/c2an35042d – volume: 1763 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib26 article-title: Sips adsorption model for DNA sensing with AlGaN/GaN high electron mobility transistors publication-title: MRS Proc. doi: 10.1557/opl.2015.131 – volume: 16 start-page: R961 year: 2004 ident: 10.1016/j.bios.2019.01.001_bib30 article-title: GaN-based diodes and transistors for chemical, gas, biological and pressure sensing publication-title: J. Phys. Condens. Matter doi: 10.1088/0953-8984/16/29/R02 – volume: 111 start-page: 1805 year: 2003 ident: 10.1016/j.bios.2019.01.001_bib31 article-title: C-reactive protein: a critical update publication-title: J. Clin. Invest. doi: 10.1172/JCI200318921 – volume: 35 start-page: 50 year: 2012 ident: 10.1016/j.bios.2019.01.001_bib14 article-title: An integrated microfluidic system for rapid screening of alpha-fetoprotein-specific aptamers publication-title: Biosens. Bioelectron. doi: 10.1016/j.bios.2012.02.024 – volume: 9 start-page: 4572 year: 2015 ident: 10.1016/j.bios.2019.01.001_bib20 article-title: Fabrication of high-performance ultrathin In2O3 film field-effect transistors and biosensors using chemical lift-off lithography publication-title: ACS Nano doi: 10.1021/acsnano.5b01211 – volume: 4 start-page: 340 year: 2014 ident: 10.1016/j.bios.2019.01.001_bib9 article-title: Detection of the inflammation biomarker C-reactive protein in serum samples: towards an optimal biosensor formula publication-title: Biosensors doi: 10.3390/bios4040340 – volume: 91 start-page: 112106 year: 2007 ident: 10.1016/j.bios.2019.01.001_bib17 article-title: Prostate specific antigen detection using AlGaN∕GaN high electron mobility transistors publication-title: Appl. Phys. Lett. doi: 10.1063/1.2772192 – volume: 9 start-page: 537 year: 2010 ident: 10.1016/j.bios.2019.01.001_bib19 article-title: Aptamers as therapeutics publication-title: Nat. Rev. Drug Discov. doi: 10.1038/nrd3141 – volume: 113 start-page: 2335 year: 2006 ident: 10.1016/j.bios.2019.01.001_bib47 article-title: Biomarkers of cardiovascular disease: molecular basis and practical considerations publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.104.482570
SSID	ssj0007190
Score	2.5458562
Snippet	Certain blood-borne biomarkers offer a potent methodology for understanding the risk of cardiovascular diseases (CVDs) with clinicians generally advocating the...
SourceID	proquest pubmed crossref elsevier
SourceType	Aggregation Database Index Database Enrichment Source Publisher
StartPage	155
SubjectTerms	Aptamers Biomarkers biosensors C-reactive protein Cardiovascular diseases fibrinogen Field-effect transistors Microfluidics natriuretic peptides oligonucleotides point-of-care systems portable equipment prototypes risk transistors troponin I
Title	An integrated microfluidic system with field-effect-transistor sensor arrays for detecting multiple cardiovascular biomarkers from clinical samples
URI	https://dx.doi.org/10.1016/j.bios.2019.01.001 https://www.ncbi.nlm.nih.gov/pubmed/30703568 https://www.proquest.com/docview/2179428016 https://www.proquest.com/docview/2189537008
Volume	129
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CSqE9lDZ9bR9Bhd6KutbKklbHJTRsW5pLG8jN6GVwSbzBu3vIpX-if7gzlr1toN1DwWBsJCOk8cwn6ZtPAG-jCT4aI3mNwZOX0gnu5slyCp0q-VgXntYhv5zp5Xn56UJdHMDJmAtDtMrB92ef3nvr4c106M3pddNMv5KEHoIRtCHZp5RSBntpyMrf__hN8zAir7OQ3h6VHhJnMsfLNyuS7Ba2l-4cDob5S3D6F_jsg9DpQ3gwoEe2yA18BAepPYK7-TzJmyO4_4e64GP4uWjZTg0isiui3tWX2yY2gWUBZ0arsKwnsfFM7OAbil29dAhb4wwXb67r3M2aIbhlMdGWA36cjTxEFm7xWRll8xPhp8MK3eqKjYmXbO1Ihnj9BM5PP3w7WfLhDAYeEMpsuLHWCbxKLeuZlD7hjFJ76ZTzvpRlxH6NelbbwteFQ7gjnJXOmVRo70QqrHwKh-2qTc-BhaKepdIHEXASFxXijLmslbYhGG2jLCYgxs6vwiBQTudkXFYjE-17RQNW0YBVhSA63gTe7epcZ3mOvaXVOKbVLSOrMH7srfdmNIAK_z7aUnFtWm2xEPmzGUZ5va_M3CppEGxN4Fm2nl1be4-r9PzFf7bsJdyjJyLFCfUKDjfdNr1GlLTxx_1vcAx3Fh8_L89-ARe9FCk
linkProvider	Elsevier
linkToHtml	http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEB3SDaXpIbRpm2w_VeitmLVWlrw6LiFh0yR7aQK5GX0ZXBJv8O4e8jvyhztj2UsD7R4KBoMtGSGNZ56kN08A33zurM9zkZQYPJNMGJ6YSdAJhU4ZrC9TS-uQl3M1u85-3MibHTjuc2GIVtn5_ujTW2_dPRl1vTm6r6rRT5LQQzCCNiTalNJnsEvqVHIAu9Oz89l845BzHpdaSHKPKnS5M5HmZasFqXZz3ap3dmfD_CU-_Qt_tnHo9BXsdwCSTWMbX8NOqA_geTxS8uEAXv4hMPgGHqc12whCeHZH7Lvydl35yrGo4cxoIZa1PLYkcjuSFYWvVj2ELXGSizfTNOZhyRDfMh9o1wE_znoqInNPKK2MEvqJ89NghWZxx_rcS7Y0pES8fAvXpydXx7OkO4YhcYhmVkmuteF4ZUqUYyFswEmlssJIY20mMo_96tW41KktU4OIhxstjMlDqqzhIdXiHQzqRR2OgLm0HIfMOu5wHuclQo2JKKXSzuVKe5EOgfedX7hOo5yOyrgtejLar4IGrKABK1JOjLwhfN_UuY8KHVtLy35Miyd2VmAI2Vrva28ABf6AtKti6rBYYyFyaWMM9GpbmYmWIke8NYTDaD2btrZOV6rJ-_9s2Rd4Mbu6vCguzubnH2CP3hBHjsuPMFg16_AJQdPKfu5-it95qhba
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=An+integrated+microfluidic+system+with+field-effect-transistor+sensor+arrays+for+detecting+multiple+cardiovascular+biomarkers+from+clinical+samples&rft.jtitle=Biosensors+%26+bioelectronics&rft.au=Sinha%2C+Anirban&rft.au=Tai%2C+Tse-Yu&rft.au=Li%2C+Kuang-Hsien&rft.au=Gopinathan%2C+Priya&rft.date=2019-03-15&rft.issn=1873-4235&rft.eissn=1873-4235&rft.volume=129&rft.spage=155&rft_id=info:doi/10.1016%2Fj.bios.2019.01.001&rft.externalDBID=NO_FULL_TEXT
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0956-5663&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0956-5663&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0956-5663&client=summon