Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats

• Published in: Journal of ethnopharmacology Vol. 75; no. 1; pp. 33 - 36
• Main Authors: Guerrero, M.F., Carrón, R., Martı́n, M.L., San Román, L., Reguero, M.T.
• Format: Journal Article
• Language: English
• Published: Shannon Elsevier Ireland Ltd 01.04.2001; Elsevier
• Subjects: Animals; Antihypertensive; Antihypertensive Agents - pharmacology; Biological and medical sciences; Blood Pressure - drug effects; Croton schiedeanus Schlecht; Euphorbiaceae - chemistry; General pharmacology; Heart Rate - drug effects; Isolated aorta; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Rats; Rats, Inbred SHR; Rats, Wistar; Spontaneously hypertensive rats; Vasodilator Agents - pharmacology; South America; Colombia; America; Antihypertensive; Spontaneously hypertensive rats; Isolated aorta; Croton schiedeanus Schlecht; Vasodilator agent; Rat; Cardiovascular disease; Vasodilation; Medicinal plant; Folk medicine; Dicotyledones; Blood vessel; Angiospermae; Euphorbiaceae; Aorta; Phytotherapy; Hypertension; Pharmacognosy; Rodentia; In vitro; Artery; Biological activity; In vivo; Vertebrata; Mammalia; Treatment; Animal; Plant origin; Antihypertensive agent; Spermatophyta; Circulatory system
• ISSN: 0378-8741; 1872-7573
• DOI: 10.1016/S0378-8741(00)00391-3

Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5–100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart rate (HR). Additionally, AECS (10 −6–3×10 −3g/ml) completely relaxed the contractions induced by high K + concentrations in intact rat aortic rings in a concentration-dependent manner.