The specific dopamine uptake inhibitor GBR 12783 improves learning of inhibitory avoidance and increases hippocampal acetylcholine release

• Published in: Brain research. Cognitive brain research Vol. 7; no. 2; pp. 203 - 205
• Main Authors: Nail-Boucherie, K, Dourmap, N, Jaffard, R, Costentin, J
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.10.1998; Elsevier Science
• Subjects: Acetylcholine - metabolism; Acetylcholine release; Animals; Avoidance Learning - drug effects; Behavior, Animal - drug effects; Behavioral psychophysiology; Biological and medical sciences; Dopamine uptake inhibitor; Dopamine Uptake Inhibitors - pharmacology; Fundamental and applied biological sciences. Psychology; Hippocampus; Hippocampus - chemistry; Hippocampus - metabolism; Male; Microdialysis; Muscarinic Antagonists - pharmacology; Muscarinic receptor antagonist; Neurotransmission and behavior; Passive avoidance test; Piperazines - pharmacology; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rat; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic - physiology; Scopolamine Hydrobromide - pharmacology; Muscarinic receptor antagonist; Passive avoidance test; Rat; DA=dopamine; Dopamine uptake inhibitor; Acetylcholine release; Hippocampus; ACh=acetylcholine; Memory; Central nervous system; Male; Cognition; Learning; Cholinergic receptor; Acquisition process; Synaptic transmission; Release; Dopamine; Electrical stimulus; Rodentia; Instrumental conditioning; Catecholamine; Uptake; Vertebrata; Mammalia; Animal; Neurotransmitter; Acetylcholine; Inhibitor; Muscarinic receptor; Avoidance; Brain (vertebrata)
• ISSN: 0926-6410
• DOI: 10.1016/S0926-6410(98)00023-8

The specific dopamine uptake inhibitor, GBR 12783 was tested on the retention performance of a one-trial passive avoidance test. For a moderate electric shock intensity, GBR 12783 (10 mg/kg), injected before acquisition session, improved retention performance. Scopolamine (0.125–0.5 mg/kg) completely blocked the promnesic effect of GBR 12783. Moreover, GBR 12783 increased hippocampal acetylcholine release in vivo. These data suggest that the promnesic effect of GBR 12783 is mediated by an increase in the septo-hippocampal cholinergic transmission.