Fortified interpenetrating polymers - bacteria resistant coatings for medical devices

Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bact...

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Published inJournal of materials chemistry. B, Materials for biology and medicine Vol. 4; no. 32; pp. 5405 - 5411
Main Authors Venkateswaran, Seshasailam, Henrique Dos Santos, Orlando David, Scholefield, Emma, Lilienkampf, Annamaria, Gwynne, Peter J, Swann, David G, Dhaliwal, Kevin, Gallagher, Maurice P, Bradley, Mark
Format Journal Article
LanguageEnglish
Published England 01.01.2016
Subjects
Antiinfectives and antibacterials
Bacteria
Coatings
Klebsiella
Klebsiella pneumoniae
Medical devices
Nanostructure
Reduction
Staphylococcus aureus
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Summary:Infections arising from contaminated medical devices are a serious global issue, contributing to antibiotic resistance and imposing significant strain on healthcare systems. Since the majority of medical device-associated infections are biofilm related, efforts are being made to generate either bacteria-repellent or antibacterial coatings aimed at preventing bacterial colonisation. Here, we utilise a nanocapsule mediated slow release of a natural antimicrobial to improve the performance of a bacteria repellent polymer coating. Poly(lauryl acrylate) nanocapsules containing eugenol (4-allyl-2-methoxyphenol) were prepared and entrapped within a interpenetrating network designed to repel bacteria. When coated on a catheter and an endotracheal tube, this hemocompatible system allowed slow-release of eugenol, resulting in notable reduction in surface-bound and methicillin resistant
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ISSN:2050-750X
2050-7518
DOI:10.1039/c6tb01110a