Phylogenetic analysis and molecular characteristics of 17 porcine reproductive and respiratory syndrome virus isolates in Southern China from 2010 to 2011

• Published in: Microbial pathogenesis Vol. 65; pp. 67 - 72
• Main Authors: Zhang, Minze, Xie, Jiexiong, Sun, Long, Cao, Zhenpeng, Gu, Honglang, Deng, Shengchao, Chen, Yao, Cao, Zongxi, Tang, Fengfeng, Su, Shuo, Zhang, Guihong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2013
• Subjects: Amino Acid Sequence; Animals; Base Sequence; China - epidemiology; Complete genome; disease control; Genetic Variation; Genome, Viral; Genotype; GP5; industry; livestock breeding; Molecular Sequence Data; Nsp2; nucleotide sequences; Phylogeny; Porcine Reproductive and Respiratory Syndrome - epidemiology; Porcine Reproductive and Respiratory Syndrome - immunology; Porcine Reproductive and Respiratory Syndrome - virology; Porcine reproductive and respiratory syndrome virus; Porcine respiratory and reproductive syndrome virus - classification; Porcine respiratory and reproductive syndrome virus - genetics; Porcine respiratory and reproductive syndrome virus - isolation & purification; PRRSV; Sequence Alignment; Sequence Analysis, DNA; Swine; vaccines; Vaccines - genetics; viruses; China; Nsp2; Complete genome; GP5; PRRSV
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2013.09.005

We analyzed the complete genomic sequences of 17 porcine reproductive and respiratory syndrome virus (PRRSV) isolates from Southern China obtained between 2010 and 2011 and found that four of seven isolates from 2011 were closely related to the JXA1-R strain (vaccine virus of JXA1). This close relationship between field isolates and China domestic vaccine viruses has not been reported to date. The occurrence of vaccine-like viruses potentially creates a threat for the pig breeding industry and brings difficulties for control of this disease. •We analyzed here the complete genomes of 17 PRRSV isolates in Southern China.•We found that four of 7 isolates from 2011 were closely related to the JXA1-R strain (vaccine virus of JXA1).•This intimate relationship between field isolates and China domestic vaccines was the first reported to date.