Diabetic ketoacidosis. Biochemistry, physiology, treatment, and prevention

Diabetic ketoacidosis (DKA) is the most common cause of death of juvenile-onset diabetics, and as such represents an important issue for pediatricians. In this article, the author reviews the endocrinology of insulin and the glucose counter-regulatory hormones, which are the basis for the developmen...

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Bibliographic Details
Published inThe Pediatric clinics of North America Vol. 34; no. 4; p. 935
Main Author Krane, E J
Format Journal Article
LanguageEnglish
Published United States 01.08.1987
Subjects
Central Nervous System Diseases - etiology
Child
Diabetic Ketoacidosis - metabolism
Diabetic Ketoacidosis - therapy
Hormones - metabolism
Humans
Hyperglycemia - metabolism
Hyperglycemia - physiopathology
Insulin - metabolism
Insulin - therapeutic use
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Summary:Diabetic ketoacidosis (DKA) is the most common cause of death of juvenile-onset diabetics, and as such represents an important issue for pediatricians. In this article, the author reviews the endocrinology of insulin and the glucose counter-regulatory hormones, which are the basis for the development of DKA. The effects of hyperglycemia and acidosis upon organ physiology are detailed, and this serves as the foundation for subsequent discussion of the management of the patient with DKA. Finally, the author summarizes current strategies for prevention of DKA in patients with diabetes.
ISSN:0031-3955
DOI:10.1016/S0031-3955(16)36296-4