Intravitreal conbercept injection for neovascular age-related macular degeneration

• Published in: International journal of ophthalmology Vol. 12; no. 2; pp. 252 - 257
• Main Authors: Wu, Bing-Hui, Wang, Bing, Wu, Hui-Qin, Chang, Qin, Lu, Hui-Qin
• Format: Journal Article
• Language: English
• Published: China International Journal of Ophthalmology Press 18.02.2019; Press of International Journal of Ophthalmology (IJO PRESS)
• Subjects: age-related macular degeneration; Clinical Research; conbercept; intravitreal injection; age-related macular degeneration; conbercept; intravitreal injection
• ISSN: 2222-3959; 2227-4898
• DOI: 10.18240/ijo.2019.02.11

To evaluate the efficacy and safety of intravitreal injection of conbercept in patients with neovascular age-related macular degeneration (AMD). Retrospective review of 66 eyes of 63 patients with neovascular AMD. All patients received 0.5 mg intravitreal injections of conbercept monthly for 3 consecutive months, and then treatment was performed. The changes of best-corrected visual acuity (BCVA) and central macular thickness (CMT) were observed before and after treatments. Minimum follow-up time was 12mo. SPSS 22.0 statistical software was used for statistical analysis. The mean BCVA and CMT of 66 eyes (63 patients) were 1.11±0.60, 533.20±219.95 µm at baseline, and were 0.68±0.38, 310.28±125.60 µm at 3mo. No subjects were lost during the first three months, the improvements were all significantly ( <0.05). During the whole follow-up time of 12mo, 15 subjects (18 eyes) were lost. The mean BCVA and CMT of the rest 48 eyes with the follow-up time at least 1y were 0.83±0.46 and 547.59±196.77 µm at baseline, after 3mo and 12mo of conbercept injections became 0.55±0.41, 318.24±141.29 µm and 0.55±0.51, 333.87±173.25 µm. The differences were significant ( <0.05). No serious complications were observed. Intravitreal injection of conbercept appears to significantly improve visual acuity and anatomical outcomes in patients with neovascular AMD, no serious adverse reactions and complications are observed.