Atropine in the treatment of baclofen overdose

• Published in: The American journal of emergency medicine Vol. 4; no. 6; pp. 552 - 553
• Main Authors: Cohen, Michael B., Gailey, Ronald A., McCoy, Guy C.
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Elsevier Inc 01.11.1986; Elsevier
• Subjects: Adolescent; Atropine; Atropine - therapeutic use; baclofen; Baclofen - poisoning; Biological and medical sciences; Bradycardia - chemically induced; Bradycardia - drug therapy; Drug intoxications. Doping; Humans; Hypotension - chemically induced; Hypotension - drug therapy; Male; Medical sciences; Pharmacology. Drug treatments; poisoning; toxicology; toxicology; Atropine; poisoning; baclofen; Human; Bradycardia; Chemotherapy; Treatment; Antispasmodic agent; Arterial hypotension; Drug intoxication; Oral administration; Cardiovascular disease; Resuscitation

A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and bl...