Atropine in the treatment of baclofen overdose

A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and bl...

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Bibliographic Details
Published inThe American journal of emergency medicine Vol. 4; no. 6; pp. 552 - 553
Main Authors Cohen, Michael B., Gailey, Ronald A., McCoy, Guy C.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Elsevier Inc 01.11.1986
Elsevier
Subjects
Adolescent
Atropine
Atropine - therapeutic use
baclofen
Baclofen - poisoning
Biological and medical sciences
Bradycardia - chemically induced
Bradycardia - drug therapy
Drug intoxications. Doping
Humans
Hypotension - chemically induced
Hypotension - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
poisoning
toxicology
toxicology
Atropine
poisoning
baclofen
Human
Bradycardia
Chemotherapy
Treatment
Antispasmodic agent
Arterial hypotension
Drug intoxication
Oral administration
Cardiovascular disease
Resuscitation
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Summary:A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
ISSN:0735-6757
1532-8171
DOI:10.1016/S0735-6757(86)80018-3