Atropine in the treatment of baclofen overdose

A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and bl...

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Published inThe American journal of emergency medicine Vol. 4; no. 6; pp. 552 - 553
Main Authors Cohen, Michael B., Gailey, Ronald A., McCoy, Guy C.
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Elsevier Inc 01.11.1986
Elsevier
Subjects
Adolescent
Atropine
Atropine - therapeutic use
baclofen
Baclofen - poisoning
Biological and medical sciences
Bradycardia - chemically induced
Bradycardia - drug therapy
Drug intoxications. Doping
Humans
Hypotension - chemically induced
Hypotension - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
poisoning
toxicology
toxicology
Atropine
poisoning
baclofen
Human
Bradycardia
Chemotherapy
Treatment
Antispasmodic agent
Arterial hypotension
Drug intoxication
Oral administration
Cardiovascular disease
Resuscitation
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Abstract A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
AbstractList A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
Author Gailey, Ronald A.
Cohen, Michael B.
McCoy, Guy C.
Author_xml – sequence: 1
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  givenname: Guy C.
  surname: McCoy
  fullname: McCoy, Guy C.
  organization: The Department of Medicine, Albany Medical College, Albany, New York, USA
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Cites_doi 10.1136/pgmj.57.671.580
10.1136/pgmj.56.662.865
10.1212/WNL.26.11.1105
10.5694/j.1326-5377.1976.tb140942.x
10.1136/pgmj.56.652.108
10.1016/S0196-0644(83)80562-9
10.3109/15563658308990050
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Issue 6
Keywords toxicology
Atropine
poisoning
baclofen
Human
Bradycardia
Chemotherapy
Treatment
Antispasmodic agent
Arterial hypotension
Drug intoxication
Oral administration
Cardiovascular disease
Resuscitation
Language English
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PublicationTitle The American journal of emergency medicine
PublicationTitleAlternate Am J Emerg Med
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References (bib1) 1980
Lipscomb, Meredith (bib4) 1980; 56
Paulson (bib3) 1976; 26
Ghose, Holmes, Mattewson (bib5) 1980; 57
Jones, Lance (bib2) 1976; 1
Ferner (bib6) 1981; 57
May (bib7) 1983; 12
Haubenstock, Hruby, Jager (bib8) 1983; 20,1
Ferner (10.1016/S0735-6757(86)80018-3_bib6) 1981; 57
Jones (10.1016/S0735-6757(86)80018-3_bib2) 1976; 1
Lipscomb (10.1016/S0735-6757(86)80018-3_bib4) 1980; 56
Ghose (10.1016/S0735-6757(86)80018-3_bib5) 1980; 57
(10.1016/S0735-6757(86)80018-3_bib1) 1980
Haubenstock (10.1016/S0735-6757(86)80018-3_bib8) 1983; 20,1
May (10.1016/S0735-6757(86)80018-3_bib7) 1983; 12
Paulson (10.1016/S0735-6757(86)80018-3_bib3) 1976; 26
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Snippet A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as...
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SubjectTerms Adolescent
Atropine
Atropine - therapeutic use
baclofen
Baclofen - poisoning
Biological and medical sciences
Bradycardia - chemically induced
Bradycardia - drug therapy
Drug intoxications. Doping
Humans
Hypotension - chemically induced
Hypotension - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
poisoning
toxicology
Title Atropine in the treatment of baclofen overdose
URI https://dx.doi.org/10.1016/S0735-6757(86)80018-3
https://www.ncbi.nlm.nih.gov/pubmed/3778604
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