Hypergonadotropic hypogonadic amenorrhea (World Health Organization III) and osteoporosis

• Published in: Fertility and sterility Vol. 57; no. 1; pp. 37 - 41
• Main Authors: Metka, Markus, Holzer, Gerold, Heytmanek, Günther, Huber, Johannes
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.01.1992; Elsevier Science
• Subjects: Adult; Amenorrhea - complications; Amenorrhea - drug therapy; Amenorrhea - physiopathology; Biological and medical sciences; Bone Density; Estradiol - blood; Estrogen Replacement Therapy; Female; Follicle Stimulating Hormone - blood; Hormones. Endocrine system; Humans; Luteinizing Hormone - blood; Medical sciences; Osteoporosis - complications; Pharmacology. Drug treatments; Primary Ovarian Insufficiency - complications; Primary Ovarian Insufficiency - drug therapy; Primary Ovarian Insufficiency - physiopathology; Reference Values; Endocrinopathy; Human; Prevention; Hypothalamohypophysogonadal axis disorders; Osteoporosis; Hypergonadotropic hypogonadism; Replacement therapy; Ovarian failure; Diseases of the osteoarticular system; Female; Sex steroid hormone
• ISSN: 0015-0282; 1556-5653
• DOI: 10.1016/S0015-0282(16)54773-6

To assess the bone mineral density in World Health Organization (WHO) III women after hormone replacement therapy. We studied the bone mineral density of 41 women with premature ovarian failure (hypergonadotropic hypogonadic amenorrhea—WHO III) before and during hormone replacement therapy. All WHO III women were recruited from the Outpatient Department of the First Department of Gynecology and Obstetrics, University of Vienna Medical School, Austria, a public University Hospital. Forty-one patients, 30 healthy women. Twenty-eight of 41 WHO III women received cyclic hormone replacement therapy consisting of 0.625 mg conjugated estrogen (days 1 to 30) and 5 mg medrogeston (days 20 to 30) in addition, with a 7-day interval. The bone mineral density was evaluated by single photon absorptiometry and dual energy x ray absorptiometry every 6 months (single photon absorptiometry six times, dual energy x ray absorptiometry four times). The bone mineral density in young women with hypergonadotropic hypogonadic amenorrhea (WHO III) was lower than in age-matched controls. Hormone replacement therapy produced an increase in bone mineral density in 28 WHO III women, whereas bone mineral density remained quite constant in the women without therapy. Hormone replacement therapy increases the bone mineral density of women with hypergonadotropic hypogonadic amenorrhea. Hormones should be substituted early and consistently in affected patients.