Involvement of EBV-encoded BART-miRNAs and dysregulated cellular miRNAs in nasopharyngeal carcinoma genesis

The definite molecular mechanisms underlying the genesis of nasopharyngeal carcinomas (NPCs) remain to be completely elucidated. miRNAs are small non-coding RNAs which are implicated in cell proliferation, apoptosis, and even carcinogenesis through negatively regulating gene expression post-transcri...

Full description

Saved in:
Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 14; no. 10; pp. 5637 - 5644
Main Authors Xie, Yuan-Jie, Long, Zhi-Feng, He, Xiu-Sheng
Format Journal Article
LanguageEnglish
Published Thailand 01.01.2013
Subjects
Animals
Carcinoma
Carrier Proteins - genetics
Herpesvirus 4, Human - genetics
Humans
MicroRNAs - genetics
Nasopharyngeal Carcinoma
Nasopharyngeal Neoplasms - genetics
Online AccessGet full text

Cover

More Information
Summary:The definite molecular mechanisms underlying the genesis of nasopharyngeal carcinomas (NPCs) remain to be completely elucidated. miRNAs are small non-coding RNAs which are implicated in cell proliferation, apoptosis, and even carcinogenesis through negatively regulating gene expression post-transcriptionally. EBV was the first human virus found to express miRNAs. EBV-encoded BART-miRNAs and dysregulated cellular miRNAs are involved in carcinogenesis of NPC by interfering in the expression of viral and host cell genes related to immune responses and perturbing signal pathways of proliferation, apoptosis, invasion, metastasis and even radio-chemo-therapy sensitivity. Additional studies on the roles of EBV-encoded miRNAs and cellular miRNAs will provide new insights concerning the complicated gene regulated network and shed light on novel strategies for the diagnosis, therapy and prognosis of NPC.
ISSN:1513-7368
2476-762X
DOI:10.7314/apjcp.2013.14.10.5637