Three new compounds isolated from the whole plants of Salsola collina pall

• Published in: Natural product research Vol. 37; no. 15; pp. 2551 - 2558
• Main Authors: Wang, Wen-Zhi, Zhan, Zhao-Chun, Tang, Qing, Yan, Ming, Chen, Neng-Hua, Zhao, Hai-Yue, Zhu, Hao-Yue, Zhang, Huan-Qing, Wu, Zhong-Nan, Wang, Hao-Yun, Zhang, Yu-Bo, Wang, Guo-Cai, Li, Yao-Lan
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.08.2023; Taylor & Francis Ltd
• Subjects: alkaloid; Alkaloids; Animals; anti-inflammatory activity; Anti-inflammatory agents; Benzofuran; Crystallography; Inflammation; Interleukin 6; lignan; Lignans; Macrophages; Mice; Molecular Structure; NMR; Nuclear magnetic resonance; RAW 264.7 Cells; Salsola - chemistry; Salsola collina; Salsola collina Pall; Tumor Necrosis Factor-alpha; Tumor necrosis factor-α; X-ray crystallography; Salsola collina Pall; lignan; alkaloid; anti-inflammatory activity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2055556

One new alkaloid, 6, 7-dimethoxyisoquinoline-N-oxide (1), one new benzofuran derivative, 3,7-dimethyl-6-acetyl-8-benzofuranol (2) and one new lignan, salsolains A (3), along with seven known compounds (4-10), were isolated from the whole plant of Salsola collina Pall. Their structures were elucidated by extensive analysis of spectroscopic data (IR, UV, HR-ESI-MS, 1 D and 2 D NMR), and their absolute configurations were determined by the X-ray crystallography and ECD calculation. The activities of compounds 1-10 against inflammatory cytokines IL-6 and TNF-α levels on LPS-induced RAW 264.7 macrophages were assessed, especially, compound 5 (50 μM) exhibited the most significant anti-inflammatory activity with the secretion levels of IL-6 and TNF-α at 3.87% and 4.03%, respectively.