Exposure of intestinal segments to hemiacidrin: analysis of metabolic and histological effects using a rat model

Using a previously reported rat model, we examined the effects of intestinal perfusion with hemiacidrin on calcium and magnesium homeostasis, and inspected the intestinal segments for histological alterations following exposure to the solution. Intestinal irrigation with hemiacidrin resulted in a si...

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Bibliographic Details
Published inThe Journal of urology Vol. 152; no. 2 Pt 2; p. 725
Main Authors Brandell, R A, Hall, M C, Koch, M O, Braren, H V
Format Journal Article
LanguageEnglish
Published United States 01.08.1994
Subjects
Animals
Calcium - metabolism
Citrates - administration & dosage
Citrates - pharmacology
Ileum - drug effects
Ileum - metabolism
Ileum - pathology
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Magnesium - metabolism
Male
Rats
Rats, Wistar
Therapeutic Irrigation
Urinary Diversion
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Summary:Using a previously reported rat model, we examined the effects of intestinal perfusion with hemiacidrin on calcium and magnesium homeostasis, and inspected the intestinal segments for histological alterations following exposure to the solution. Intestinal irrigation with hemiacidrin resulted in a significant increase in serum magnesium. Urinary excretion rates of calcium increased 8-fold and magnesium excretion rates increased 5-fold over control values. Hemiacidrin appeared to have detrimental effects on the integrity of the intestinal mucosa, and irrigation should be done with caution in patients whose urinary tract has been reconstructed with intestinal segments.
ISSN:0022-5347
DOI:10.1016/S0022-5347(17)32691-5