Synthesis of diacylamines and the preparation of α-amino-acylureas, a new type of α-amino acid derivatives

• Published in: Bioorganic & medicinal chemistry letters Vol. 8; no. 22; pp. 3241 - 3244
• Main Authors: Weisz, Imre, Roboz, John, Wolf, Imre, Szabo, Jozsef, Bekesi, J.George
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 17.11.1998; Elsevier
• Subjects: Aliphatic compounds; Amines - chemical synthesis; Amino Acids - chemical synthesis; Anticonvulsants - pharmacology; Antineoplastic Agents - pharmacology; Chemistry; Exact sciences and technology; Organic chemistry; Preparations and properties; Ureas; Catalytic reaction; Aminoester; Chemical synthesis; Aminoamide; Acylation
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(98)00593-9

Sixteen new and one known unsymmetrical open-chain diacylamines were synthesized by sodium methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters. 16 new and 2 known open-chain diacylamines were synthesized by Na-methoxide catalyzed acylation of amides with carboxylic esters and acylamino-carboxylic esters, or acylureas with acylamino-carboxylic esters and α-amino acid esters.