NSAIDs, gastrointestinal injury, and cytoprotection

Gastrointestinal toxicity caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is the most frequent drug side effect in the United States. NSAIDs are implicated in the development of complicated peptic ulcer disease and injury to the small bowel and colon. NSAIDs interfere with prostaglandin-medi...

Full description

Saved in:
Bibliographic Details
Published inGastroenterology clinics of North America Vol. 25; no. 2; p. 279
Main Author Scheiman, J M
Format Journal Article
LanguageEnglish
Published United States 01.06.1996
Subjects
Animals
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - economics
Cost-Benefit Analysis
Digestive System - drug effects
Digestive System - metabolism
Epithelium - drug effects
Epithelium - metabolism
Gastrointestinal Diseases - chemically induced
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - prevention & control
Humans
Mucous Membrane - drug effects
Mucous Membrane - metabolism
Prostaglandins - economics
Prostaglandins - therapeutic use
Risk Factors
Online AccessGet more information

Cover

More Information
Summary:Gastrointestinal toxicity caused by nonsteroidal anti-inflammatory drugs (NSAIDs) is the most frequent drug side effect in the United States. NSAIDs are implicated in the development of complicated peptic ulcer disease and injury to the small bowel and colon. NSAIDs interfere with prostaglandin-mediated epithelial defense mechanisms and also cause direct epithelial toxicity. Current and future approaches to the prevention and management of NSAID injury are reviewed.
ISSN:0889-8553
DOI:10.1016/s0889-8553(05)70247-8