The inhibition of trans-cinnamaldehyde on the virulence of Candida albicans via enhancing farnesol secretion with low potential for the development of resistance

• Published in: Biochemical and biophysical research communications Vol. 515; no. 4; pp. 544 - 550
• Main Authors: Ying, Li, Mingzhu, Shan, Mingju, Yan, Ye, Xu, Yuechen, Wang, Ying, Chen, Bing, Gu, Hongchun, Li, Zuobin, Zhu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.08.2019
• Subjects: adhesion; antifungal agents; antifungal properties; biofilm; Candida albicans; candidiasis; dose response; drug resistance; Farnesol; fungi; GRAS substances; Hyphae; pathogens; secretion; Trans-cinnamaldehyde; Virulence; Candida albicans; GC-MS; SD; Trans-cinnamaldehyde; DMSO; Virulence; Farnesol; AMB; MIC; Hyphae; QSM; TC
• ISSN: 0006-291X; 1090-2104; 1090-2104
• DOI: 10.1016/j.bbrc.2019.05.165

The emergence of drug resistance and limitation of antifungal agents complicate the management of fungal infection. Candida albicans, as the most common fungal infection pathogen, causes candidiasis via developing its virulence factors. In this study, we found trans-cinnamaldehyde (TC), known as a “...