The inhibition of trans-cinnamaldehyde on the virulence of Candida albicans via enhancing farnesol secretion with low potential for the development of resistance

The emergence of drug resistance and limitation of antifungal agents complicate the management of fungal infection. Candida albicans, as the most common fungal infection pathogen, causes candidiasis via developing its virulence factors. In this study, we found trans-cinnamaldehyde (TC), known as a “...

Full description

Saved in:
Bibliographic Details
Published inBiochemical and biophysical research communications Vol. 515; no. 4; pp. 544 - 550
Main Authors Ying, Li, Mingzhu, Shan, Mingju, Yan, Ye, Xu, Yuechen, Wang, Ying, Chen, Bing, Gu, Hongchun, Li, Zuobin, Zhu
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 06.08.2019
Subjects
adhesion
antifungal agents
antifungal properties
biofilm
Candida albicans
candidiasis
dose response
drug resistance
Farnesol
fungi
GRAS substances
Hyphae
pathogens
secretion
Trans-cinnamaldehyde
Virulence
Candida albicans
GC-MS
SD
Trans-cinnamaldehyde
DMSO
Virulence
Farnesol
AMB
MIC
Hyphae
QSM
TC
Online AccessGet full text

Cover

More Information
Summary:The emergence of drug resistance and limitation of antifungal agents complicate the management of fungal infection. Candida albicans, as the most common fungal infection pathogen, causes candidiasis via developing its virulence factors. In this study, we found trans-cinnamaldehyde (TC), known as a “Generally Regarded As Safe” (GRAS) molecule, had moderate antifungal activities against various Candida species and could retard the virulence of C. albicans in a dose-dependent manner by inhibiting the adhesion, morphological transition and biofilms formation. The mechanisms investigation revealed that the inhibition of hyphae and biofilms development was caused by the increasing farnesol secretion induced by Dpp3 expression. Since drug resistance restricted the treatment of clinical fungal infection, we explored the capacity of TC to develop drug-resistance under a long time TC treatment. Results showed that TC had little chance to form resistance by a serial passage experiment. Our work illustrates the underlying mechanism of TC inhibition of morphological transition and provides a optional application in treating the relevant fungal infections by targeting fungal virulence factors.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1016/j.bbrc.2019.05.165