Subacute radiation dermatitis from fluoroscopy during coronary artery stenting: Evidence for cytotoxic lymphocyte mediated apoptosis

A patient with fluoroscopy-induced subacute radiation dermatitis is described. Her biopsy specimen showed vacuolar change and necrotic keratinocytes with lymphocytes in direct apposition, or “satellitosis.” Lymphocytes in the dermis and infiltrating the epidermis were predominantly CD8 + and a numbe...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 38; no. 2; pp. 333 - 336
Main Authors Stone, Mary Seabury, Robson, Kristi J., LeBoit, Philip E.
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.02.1998
Elsevier
Subjects
Acute Disease
Apoptosis - immunology
Apoptosis - radiation effects
Biological and medical sciences
Biopsy
Coronary Angiography - adverse effects
Coronary Disease - complications
Coronary Disease - diagnostic imaging
Coronary Disease - surgery
Cytotoxicity, Immunologic - immunology
Cytotoxicity, Immunologic - radiation effects
Dermatology
Epidermis - immunology
Epidermis - pathology
Epidermis - radiation effects
Female
Fluoroscopy - adverse effects
Humans
Medical sciences
Middle Aged
Radiodermatitis - diagnosis
Radiodermatitis - etiology
Radiodermatitis - immunology
Radiography, Interventional - adverse effects
Skin involvement in other diseases. Miscellaneous. General aspects
Stents
T-Lymphocytes, Cytotoxic - immunology
T-Lymphocytes, Cytotoxic - radiation effects
Time Factors
Case study
Human
Skin disease
Radiodermatitis
Iatrogenic
Physical agent
Radiation injury
Complication
Exploration
Medical imagery
fluoroscopy
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Summary:A patient with fluoroscopy-induced subacute radiation dermatitis is described. Her biopsy specimen showed vacuolar change and necrotic keratinocytes with lymphocytes in direct apposition, or “satellitosis.” Lymphocytes in the dermis and infiltrating the epidermis were predominantly CD8 + and a number of the lymphocytes stained for TIA-1, a cytotoxic granule protein in T-cells and natural killer cells, that appears to be involved in the induction of apoptosis. Our findings suggest cytotoxic lymphocyte mediated apoptosis is involved in the pathogenesis of subacute radiation dermatitis. (J Am Acad Dermatol 1998;38:333-6.)
ISSN:0190-9622
1097-6787
DOI:10.1016/S0190-9622(98)70577-8