Strategies to load therapeutics into polysaccharide-based nanogels with a focus on microfluidics: A review

Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles f...

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Bibliographic Details
Published inCarbohydrate polymers Vol. 266; p. 118119
Main Authors Zoratto, N., Montanari, E., Viola, M., Wang, J., Coviello, T., Di Meo, C., Matricardi, P.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 15.08.2021
Subjects
Drug loading methods
Microfluidics
Nanogels
Nanogels-based vaccines
Polysaccharides
DD
TT
ALN
IDA
Pul-Ch
Drug loading methods
CMD-SS-LCA
Cs
BSA
DSB
HA-AT
rHBsAg
MA
pβ-CD
CSLNs
SpAcDEX
HCPT
ssDNA
AA
SODB1
MIC
HBsAg
MW
DOX
RGD
Gel
RA
TOPSi
CDDP
CDs
pDNA
Alg-CHO
Gel-Rfv
FA
Man
OVA
DHA
dsDNA
Microfluidics
HA-APBA
Nanogels-based vaccines
HA-Rfv
mRNA
HA-Ch
Polysaccharides
PDI
DCs
PTX
TPP
miRNA
NGs
PPZ
E.E
GSH
Nanogels
APCs
BoHc/A
Pul
siRNA
Gel-Ch
TA
AmPs
Alg-PDEA
PAA
PEG
PEI
DEX
MIVM
PIR
HA
DEAE
FNC
Alg
DA
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Summary:Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen three-dimensional network of synthetic polymers or natural macromolecules such as polysaccharides. NGs represent a highly versatile nanocarrier, able to deliver a number of therapeutics. Currently, NGs are undergoing clinical trials for the delivery of anti-cancer vaccines. Herein, the strategies to load low molecular weight drugs, (poly)peptides and genetic material into polysaccharide NGs as well as to formulate NGs-based vaccines are summarized, with a focus on the microfluidics approach. •Strategies to load therapeutics into polysaccharide nanogels have been highlighted.•The formulation of polysaccharide-based vaccines has been described.•Microfluidics for facilitating the scalability of nanogel formulations has been discussed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2021.118119