Timolol gel versus acetazolamide in the prophylaxis of ocular hypertension after phacoemulsification
Purpose: To compare postoperative intraocular pressure (IOP) after administration of acetazolamide and timolol following phacoemulsification and intraocular lens implantation. Setting: Ophthalmic Consultants of Long Island, Rockville Centre, New York, USA. Methods: Sixty patients were included in a...
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Published in | Journal of cataract and refractive surgery Vol. 23; no. 7; pp. 1070 - 1074 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Elsevier Inc
01.09.1997
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Purpose: To compare postoperative intraocular pressure (IOP) after administration of acetazolamide and timolol following phacoemulsification and intraocular lens implantation.
Setting: Ophthalmic Consultants of Long Island, Rockville Centre, New York, USA.
Methods: Sixty patients were included in a prospective, randomized, masked trial. The patients received either two doses of oral, sustained-release acetazolamide (Diamox® Sequels®) or a single dose of topical timolol 0.5% gel (Timoptic XE®). Intraocular pressure was measured by Goldmann applanation tonometry preoperatively and 1 day postoperatively.
Results: Mean preoperative IOP was 16.4 mm Hg. One day postoperatively, it was 19.5 mm Hg in the oral acetazolamide group and 15.9 mm Hg in the timolol gel group. One patient in the acetazolamide group developed significant adverse reactions.
Conclusion: Prophylactic use of topical timolol 0.5% gel for viscoelastic-induced ocular hypertension after cataract extraction appears to offer better IOP control than oral acetazolamide and has potentially fewer adverse systemic effects. |
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ISSN: | 0886-3350 1873-4502 |
DOI: | 10.1016/S0886-3350(97)80082-X |