Effects of 17 β estradiol on the metabolism of labelled arachidonic acid in uteri isolated from intact and ovariectomized rats. Influence of a restricted diet
The effects of restricted diet (50% of the normal intake during 25 days) on the metabolism of 14U arachidonic acid, were explored in uterine horn strips isolated from intact and ovariectomized rats, treated by 17 β-estradiol or controls. The metabolism of arachidonic acid into different eicosanoids,...
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Published in | Prostaglandins, leukotrienes and essential fatty acids Vol. 56; no. 6; pp. 457 - 460 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
Kidlington
Elsevier Ltd
01.06.1997
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The effects of restricted diet (50% of the normal intake during 25 days) on the metabolism of
14U arachidonic acid, were explored in uterine horn strips isolated from intact and ovariectomized rats, treated by 17 β-estradiol or controls. The metabolism of arachidonic acid into different eicosanoids, PGE
2, PGF
2α, 6-keto PGF
1α and TXB
2, showed that the restricted diet diminished PGE
2 and PGF
2α, in intact rats, significantly. In contrast, this kind of feeding did not produce any change in castrated rats.
Tissue preparations from previously estrogenized intact and castrated normal-fed rats showed that the production of different metabolites decreased. A similar result was obtained in intact rats subjected to a restricted diet. Nevertheless, in castrated underfed rats, estrogens did not produce any effect on the various eicosanoids analysed.
These results showed that in isolated uteri, the effects of 17 β-estradiol, on metabolite production from labelled arachidonic acid, are different from controls in ovariectomized diet-restricted rats. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0952-3278 1532-2823 |
DOI: | 10.1016/S0952-3278(97)90599-8 |