Trisomy 21 and accelerated aging: DNA-repair parameters in peripheral lymphocytes of Down's syndrome patients
Down's syndrome (DS) cases from 1–40 years of age and showing no other anomalies or deficiencies were categorized into three age groups: group 1, ⩽12 years; group 2, 13–25 years; and group 3, ⩾26 years. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases,...
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Published in | Mechanisms of ageing and development Vol. 100; no. 1; pp. 85 - 101 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
12.01.1998
Elsevier Science |
Subjects | |
Online Access | Get full text |
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Summary: | Down's syndrome (DS) cases from 1–40 years of age and showing no other anomalies or deficiencies were categorized into three age groups: group 1, ⩽12 years; group 2, 13–25 years; and group 3, ⩾26 years. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases, (Total,
β and
ε) and two endodeoxyribonucleases, (UV- and AP-DNases) were assessed in the peripheral lymphocytes of these subjects (under different conditions) along with age and sex matched normal healthy human subjects. The DS group showed lower DNA-repair efficiency and also an accelerated decline in DNA-repair capacity with age. These results indicate that deteriorated DNA-repair potential could be one of the probable reasons for premature aging seen in this chromosomal disorder. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0047-6374 1872-6216 |
DOI: | 10.1016/S0047-6374(97)00121-8 |