Developmental changes in renal tubular function

Use of the standard measure of renal function, glomerular filtration rate when corrected for body size, indicates fully functional renal capacity by one year of age, which remains relatively constant until the fourth decade of life, when it begins to gradually decline with advancing age. The active...

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Bibliographic Details
Published inJournal of adolescent health Vol. 15; no. 8; pp. 648 - 653
Main Author Linday, Linda A.
Format Journal Article Conference Proceeding
LanguageEnglish
Published New York, NY Elsevier Inc 01.12.1994
Elsevier Science
Subjects
Adolescence Renal function Renal tubular excretion
Adolescent
Adult
Age Factors
Aged
Animals
Anions
Biological and medical sciences
Cations
Child
Digoxin - metabolism
Drug Interactions
Female
General pharmacology
Glomerular Filtration Rate
Humans
Infant, Newborn
Kidney Tubules - growth & development
Kidney Tubules - physiology
Kidney Tubules - secretion
Linear Models
Male
Medical sciences
Middle Aged
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology
Pharmacology. Drug treatments
Purines - metabolism
Rats
Uric Acid - blood
Uric Acid - urine
Adolescence Renal function Renal tubular excretion
Human
Sexual maturation
Drug
Puberty
Renal tubule
Renal function
Adolescent
Development
Pharmacokinetics
Age
Kidney
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Summary:Use of the standard measure of renal function, glomerular filtration rate when corrected for body size, indicates fully functional renal capacity by one year of age, which remains relatively constant until the fourth decade of life, when it begins to gradually decline with advancing age. The active tubular secretion and reabsorption of cations and anions provide an occasion for drug interactions which are difficult to predict without knowledge of the exact mechanisms involved. Data support developmental changes in net tubular secretion for some substances. For digoxin, the larger ratio of digoxin clearance to creatinine clearance that is observed in children decreases during adolescence to the lower ratio observed in adults, and this decrement is better correlated with sexual maturation than with chronologic age. Thus for drugs with significant renal excretion of active drug or metabolite, the clarification of net renal tubular mechanisms would provide important clinical information.
ISSN:1054-139X
1879-1972
DOI:10.1016/S1054-139X(94)90632-7