Low intensities and 1.3 ratio produce distortion product otoacoustic emissions which are larger in heterozygous (+/ dn) than homozygous (+/+) mice

• Published in: Hearing research Vol. 117; no. 1; pp. 24 - 30
• Main Authors: Huang, Jer-Min, Berlin, Charles I, Lin, Shu-Tze, Keats, Bronya J.B
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.1998; Elsevier
• Subjects: Acoustic Stimulation; Animals; Biological and medical sciences; Curly-tail mouse; Deafness - genetics; Deafness mouse; Disease Models, Animal; Distortion product otoacoustic emission; dn gene carrier; Ear, auditive nerve, cochleovestibular tract, facial nerve: diseases, semeiology; Female; Heterozygote; Homozygote; Male; Medical sciences; Mice; Non tumoral diseases; Otoacoustic Emissions, Spontaneous - genetics; Otorhinolaryngology. Stomatology; Phenotype; Deafness mouse; dn gene carrier; Curly-tail mouse; Distortion product otoacoustic emission; Vertebrata; Mammalia; Otoacoustic emission; Mouse; Animal; Rodentia; Auditory disorder; ENT disease; Distortion; Low intensity; Mutation; Hearing loss
• ISSN: 0378-5955; 1878-5891
• DOI: 10.1016/S0378-5955(98)00005-7

The f 2/ f 1 frequency ratio of 1.3 in combination with stimulus levels of L 1/L 2=50/60 and 50/50 dB SPL produced a higher level of distortion product otoacoustic emissions (DPOAE) in the heterozygous (+/ dn) mice than in the homozygous (+/+) mice. These results suggest that the dn gene carriers have a unique cochlear trait which may be related to the dn gene locus and expressed via a frequency- and intensity-dependent DPOAE function.