Cytogenetic abnormalities associated with renal cell carcinoma

• Published in: The Journal of urology Vol. 146; no. 3; p. 692
• Main Authors: Maloney, K E, Norman, R W, Lee, C L, Millard, O H, Welch, J P
• Format: Journal Article
• Language: English
• Published: United States 01.09.1991
• Subjects: Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell - complications; Carcinoma, Renal Cell - genetics; Chromosome Aberrations; Chromosomes, Human, Pair 3; Chromosomes, Human, Pair 7; Female; Humans; Karyotyping; Kidney Neoplasms - complications; Kidney Neoplasms - genetics; Male; Middle Aged; von Hippel-Lindau Disease - complications; von Hippel-Lindau Disease - genetics
• ISSN: 0022-5347
• DOI: 10.1016/S0022-5347(17)37895-3

Cytogenetic analysis was performed on 23 renal cell carcinomas (21 sporadic and 2 associated with von Hippel-Lindau's disease). Clonal chromosomal abnormalities were found in 19 of 21 of the sporadic tumors. The most frequent abnormalities were a loss or rearrangement of material in 3p (11 of 21 cases) or an extra chromosome 7 (7 of 21 cases). Correlation between specific chromosomal abnormalities and clinical presentation was absent with the exception of trisomy 7 and -Y, which occurred only in patients more than 60 years old. An increasing number of cytogenetic abnormalities were associated with a greater likelihood of renal vein and/or capsule involvement. Both patients with von Hippel-Lindau's disease had tumors with a normal karyotype.