Can heterologous gene expression shed (a torch) light on protein function?

Heterologous gene expression is of prime importance for a wide variety of applied and basic biological research areas, including tissue engineering, gene therapy and biopharmaceutical manufacturing. [...]they support the arguments questioning the functionality of heterologously expressed proteins (e...

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Bibliographic Details
Published inTrends in biotechnology (Regular ed.) Vol. 22; no. 11; pp. 557 - 559
Main Authors Dubessay, Pascal, Pagès, Michel, Delbac, Frédéric, Bastien, Patrick, Vivares, Christian, Blaineau, Christine
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.11.2004
Elsevier Limited
Subjects
Animals
Biological research
Cell division
Encephalitozoon cuniculi - genetics
Encephalitozoon cuniculi - metabolism
Gene expression
Gene Expression Regulation - physiology
Genomics
Kinesin - genetics
Kinesin - metabolism
Leishmania major - genetics
Leishmania major - metabolism
Organisms
Protein Engineering - methods
Proteins
Recombinant Proteins - chemistry
Recombinant Proteins - metabolism
Structure-Activity Relationship
Tissue engineering
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Summary:Heterologous gene expression is of prime importance for a wide variety of applied and basic biological research areas, including tissue engineering, gene therapy and biopharmaceutical manufacturing. [...]they support the arguments questioning the functionality of heterologously expressed proteins (e.g. in plants) because the subcellular location of the latter might influence their accumulation, folding and assembly [1,2].
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2004.09.004