Paradoxical reactions to rectal midazolam as premedication in children

• Published in: International journal of oral and maxillofacial surgery Vol. 19; no. 1; pp. 2 - 6
• Main Authors: Roelofse, J.A., Stegmann, D.H., Hartshore, J., de V. Joubert, J.J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.02.1990; Elsevier
• Subjects: Administration, Rectal; Analysis of Variance; Anxiety - prevention & control; Biological and medical sciences; Chi-Square Distribution; Child; Child Behavior - drug effects; Child, Preschool; Dose-Response Relationship, Drug; Double-Blind Method; Female; Hemodynamics - drug effects; Humans; Hypnotics. Sedatives; Male; Medical sciences; midazolam; Midazolam - administration & dosage; Midazolam - adverse effects; Neuropharmacology; paradoxial reactions; Pharmacology. Drug treatments; Preanesthetic Medication - adverse effects; premedication; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; Randomized Controlled Trials as Topic; rectal; rectal; premedication; midazolam; paradoxial reactions; Human; Chemotherapy; Treatment; Tolerance; Anesthesia; Benzodiazepine derivatives; Sedative; Child; Rectal administration; Premedication
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/S0901-5027(05)80558-2

Eighty healthy children, between the ages of 2 and 7 years, who were to undergo oral surgical procedures under general anaesthesia, were allocated randomly to 4 groups. Thre groups received rectal midazolam, and the other group a placebo (saline) as premedication 30 min prior to induction of anaesthesia. Group C 0.45 mg/kg. No statistically significant difference was found between the treatment groups as to the effect on systolic- (p=0.6920) and diastolic (p=0.8701) bloodpressures, respiration (p=0.0505) and pulse (p=0.6192) rates at either pre- or post-sedation levels. However, the results indicate that levels of anxiolysis and sedation were significantly associated with midazolam dosage (p<0.0001).