Cerebral blood flow, metabolic rate, and cross-brain oxygen consumption in brain injury

• Published in: The Journal of pediatrics Vol. 107; no. 4; pp. 510 - 513
• Main Authors: Frewen, Timothy C., Sumabat, Washington O., Del Maestro, Rolando F.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.1985; Elsevier
• Subjects: Adolescent; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Blood Pressure; Brain - metabolism; Brain Injuries - metabolism; Brain Injuries - mortality; Brain Injuries - physiopathology; Cerebrovascular Circulation; Child; Child, Preschool; Drowning; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Humans; Infant; Intensive care medicine; Intracranial Pressure; Medical sciences; Oxygen Consumption; Prognosis; Human; Nervous system diseases; Craniocerebral; Oxygen consumption; Brain (Vertebrata); Metabolism; Child; Trauma; Resuscitation; Blood flow
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/S0022-3476(85)80006-8

In six deeply comatose children, the relationships of intracranial pressure, cerebral perfusion pressure,cerebral blood flow, cross-brain oxygen consumption, and metabolic rate to outcome were studied sequentially during therapy. Intracranial pressure, cross-brain oxygen consumption, and metabolic rate values were significantly different in the three children who survived compared with those in the three who died. The differences in cross-brain oxygen consumption and metabolic rate occurred in the presence of clinically acceptable values for intracranial and cerebral perfusion pressures. Cross-brain oxygen consumption and metabolic rate may be important indicators of degree of neuronal injury, and of outcome.