Zygotic-Splitting Rates after Single-Embryo Transfers in in Vitro Fertilization

To the Editor: The mechanism of spontaneous monozygotic twinning is unknown. However, on the basis of observations first made 15 years ago, it is now generally accepted that all forms of assisted conception increase the rate of zygotic splitting. 1 – 3 The true incidence of zygotic splitting is unkn...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 348; no. 23; pp. 2366 - 2367
Main Authors Jones, Christopher, Blickstein, Isaac, Keith, Louis G
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 05.06.2003
Subjects
Embryo Transfer
Female
Fertilization in Vitro
Humans
Infant, Newborn
Pregnancy
Pregnancy, Multiple - statistics & numerical data
Triplets - statistics & numerical data
Twins, Monozygotic - statistics & numerical data
Zygote
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Summary:To the Editor: The mechanism of spontaneous monozygotic twinning is unknown. However, on the basis of observations first made 15 years ago, it is now generally accepted that all forms of assisted conception increase the rate of zygotic splitting. 1 – 3 The true incidence of zygotic splitting is unknown in a substantial proportion of twins, because same-sex dizygotic twins cannot be differentiated from dichorionic monozygotic twins by either antepartum ultrasonography 4 or postpartum clinical examination. Single-embryo transfers are currently considered to be a means for minimizing the risk of multiple births with in vitro fertilization. In order to assess the risk of . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc026724