Solid-phase synthesis of di- and tripeptidic hydroxamic acids as inhibitors of procollagen C-proteinase

A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 10; no. 22; pp. 2513 - 2516
Main Authors Dankwardt, Sharon M, Billedeau, Roland J, Lawley, Linda K, Abbot, Sarah C, Martin, Robert L, Chan, Christine S, Van Wart, Harold E, Walker, Keith A.M
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 20.11.2000
Elsevier
Subjects
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Biological and medical sciences
Bone Morphogenetic Protein 1
Bone Morphogenetic Proteins - antagonists & inhibitors
Enzyme Inhibitors - chemical synthesis
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - pharmacology
Enzymes and enzyme inhibitors
Fundamental and applied biological sciences. Psychology
Hydrolases
Hydroxamic Acids - chemical synthesis
Hydroxamic Acids - chemistry
Hydroxamic Acids - pharmacology
Metalloendopeptidases - antagonists & inhibitors
Sulfur nitrogen heterocycle
Procollagen C-endopeptidase
Sulfonamide
Peptides
Enzyme
Thiazole derivatives
Tripeptide
Hydroxamic acid
Enzyme inhibitor
Metalloendopeptidases
Organic carbamate
In vitro
Biological activity
Peptidases
Dipeptides
Hydrolases
Carboxamide
Ureas
Peptide synthesis
Solid phase
Chemical synthesis
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Summary:A solid-phase approach to the rapid synthesis of di- and tripeptide-like hydroxamic acids is presented. These compounds are shown to be potent inhibitors of procollagen C-proteinase (PCP).
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/S0960-894X(00)00525-4