Ultrathin polyaniline film coated on an indium–tin oxide cell-based chip for study of anticancer effect

• Published in: Thin solid films Vol. 518; no. 2; pp. 661 - 667
• Main Authors: El-Said, Waleed Ahmed, Yea, Cheol-Heon, Choi, Jeong-Woo, Kwon, Il-Keun
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Amsterdam Elsevier B.V 30.11.2009; Elsevier
• Subjects: Anticancer drugs; Cell-based chip; Cross-disciplinary physics: materials science; rheology; Cyclic voltammetry; Exact sciences and technology; HeLa cell; Materials science; Methods of deposition of films and coatings; film growth and epitaxy; PANI; Physics; Theory and models of film growth; Cyclic voltammetry; Anticancer drugs; PANI; Cell-based chip; HeLa cell; Ultrathin films; Drugs; Morphological changes; Indium tin oxide electrode; Toxicity; Neutral solution; Chip; Indium oxide; Tin oxide; Growth mechanism; Counterions; Codeposition; Polyanilines
• ISSN: 0040-6090; 1879-2731
• DOI: 10.1016/j.tsf.2009.07.062

Polyaniline emeraldine base (EB) coated indium–tin oxide (ITO) electrode was prepared for the construction of a cell-based chip. Ultrathin polyaniline PANI film on an ITO was electroactive at neutral pH without co-deposition of an acidic counterion. HeLa cells were cultured on a PANI/ITO substrate and utilized to assess the biological toxicity of anticancer drugs. Cell growth, cell viability and drug-related cell toxicity were evaluated by a cyclic voltammetry (CV) method under a neutral pH. We demonstrated the functionality of a PANI coated ITO electrode for use as a cell chip and found that PANI was a good surface for the HeLa cells to grow without any significant morphological changes.