A NOVEL VARIANT OF STAPHYLOKINASE GENE FROM STAPHYLOCOCCUS AUREUS ATCC 29213

The processes of hemostasis and thrombolysis are elegantly regulated in order to ensure normal functions of vascular system. A search for new plasminogen activators as thrombolytic agents has been carried out for the purpose of clinical applications to modulate thrombolytic processes. In the current...

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Bibliographic Details
Published inThrombosis research Vol. 87; no. 4; pp. 387 - 395
Main Authors Kim, Seung-Ho, Chun, Hong-Sung, Han, Moon Hi, Park, Na-Young, Suk, Kyoungho
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Ltd 15.08.1997
Elsevier Science
Subjects
Amino Acid Sequence
Bacteriology
Base Sequence
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Cloning, Molecular
DNA, Complementary - genetics
DNA, Complementary - isolation & purification
fibrinolysis
Fundamental and applied biological sciences. Psychology
Genes, Bacterial
Medical sciences
Metabolism. Enzymes
Metalloendopeptidases - genetics
Microbiology
Molecular Sequence Data
Pharmacology. Drug treatments
S. aureus
Sequence Alignment
Staphylococcus aureus - genetics
staphylokinase
fibrinolysis
staphylokinase
S. aureus
Enzyme
Gene product
Transferases
Genetic variant
In vitro
Biological activity
Gene
Kinase
Bacteria
Micrococcales
Micrococcaceae
Fibrinolytic
Staphylococcus aureus
Aminoacid sequence
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Summary:The processes of hemostasis and thrombolysis are elegantly regulated in order to ensure normal functions of vascular system. A search for new plasminogen activators as thrombolytic agents has been carried out for the purpose of clinical applications to modulate thrombolytic processes. In the current work, several strains and clinical isolates of Staphylococcus aureus were screened for the fibrinolytic activity. The DNA sequences of staphylokinase gene in the strains expressing 15 kDa protein with staphylokinase activity were determined and subsequently compared with three known staphylokinase gene sequences. From the sequence comparison a new variant of staphylokinase gene has been identified in ATCC 29213 strain. The gene product needs to be further characterized and tested for the therapeutic potential. © 1997 Elsevier Science Ltd
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ISSN:0049-3848
1879-2472
DOI:10.1016/S0049-3848(97)00142-4