Host defense development in gut and related disorders

The gastrointestinal tract serves as an important interface between ingested elements from the external environment and the internal milieu of the person. Maturation of this intestinal barrier appears to occur along with the normal development of other organ systems. Evidence is presented for this m...

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Bibliographic Details
Published inThe Pediatric clinics of North America Vol. 35; no. 1; p. 1
Main Authors Israel, E J, Walker, W A
Format Journal Article
LanguageEnglish
Published United States 01.02.1988
Subjects
Celiac Disease - physiopathology
Colitis - physiopathology
Digestive System - physiopathology
Enterocolitis, Pseudomembranous - physiopathology
Food Hypersensitivity - physiopathology
Gastric Acid - metabolism
Gastroenteritis - physiopathology
Gastrointestinal Diseases - immunology
Gastrointestinal Diseases - physiopathology
Gastrointestinal Motility
Humans
Immunity, Cellular
Infant, Newborn
Intestinal Mucosa - physiopathology
Peptide Hydrolases - metabolism
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Summary:The gastrointestinal tract serves as an important interface between ingested elements from the external environment and the internal milieu of the person. Maturation of this intestinal barrier appears to occur along with the normal development of other organ systems. Evidence is presented for this maturational process, and the relation of this immature barrier to certain disease states seen in the neonatal period (e.g., infectious diarrhea, necrotizing enterocolitis, and allergic disease) is discussed.
ISSN:0031-3955
DOI:10.1016/S0031-3955(16)36396-9