Pharmacokinetic study on intravenous rifampicin in man

A pharmacokinetic study was carried out in 18 male patients in order to assess the blood concentrations of rifampicin after intravenous administration of 3 different doses (600, 900 and 1200 mg) over 3 different periods of infusion (1, 2 and 3 hours). The results show that, by increasing the dose an...

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Bibliographic Details
Published inPharmacological research communications Vol. 16; no. 7; p. 723
Main Authors Acocella, G, Segre, G, Conti, R, Pagani, V, Pallanza, R, Perna, G, Simone, P
Format Journal Article
LanguageEnglish
Published United States 01.07.1984
Subjects
Bilirubin - metabolism
Humans
Infusions, Parenteral
Kinetics
Male
Rifampin - administration & dosage
Rifampin - metabolism
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Summary:A pharmacokinetic study was carried out in 18 male patients in order to assess the blood concentrations of rifampicin after intravenous administration of 3 different doses (600, 900 and 1200 mg) over 3 different periods of infusion (1, 2 and 3 hours). The results show that, by increasing the dose and the rate of infusion higher and earlier peak concentrations are obtained. A kinetic analysis based on a one-compartment open model gives a good fitting of the data obtained experimentally. From these data one obtains for the volume of distribution a value of 48.1 +/- 17.2 liters and for the serum disappearance rate the value of 0.212 +/- 0.070 h-1 in adult subjects. It is possible to predict the time course of serum kinetics of the drug by using the equation (formula; see text).
ISSN:0031-6989
1879-2936
DOI:10.1016/S0031-6989(84)80050-8