PLA nanoparticles coated with a β-cyclodextrin polymer shell: Preparation, characterization and release kinetics of a hydrophobic compound

• Published in: International journal of pharmaceutics Vol. 436; no. 1-2; pp. 644 - 651
• Main Authors: El Fagui, Amani, Amiel, Catherine
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 15.10.2012
• Subjects: benzophenone; Benzophenones - chemistry; beta-cyclodextrin; beta-Cyclodextrins - chemistry; Calorimetry, Differential Scanning; Core–shell nanoparticles; encapsulation; Host–guest interactions; Hydrophobic and Hydrophilic Interactions; hydrophobicity; Kinetics; Lactic Acid - chemistry; Microscopy, Electron, Scanning; nanoparticles; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Polyesters; polylactic acid; Polymers - chemistry; Release kinetics; Host–guest interactions; Release kinetics; Core–shell nanoparticles
• ISSN: 0378-5173; 1873-3476
• DOI: 10.1016/j.ijpharm.2012.07.052

The aim of this work was to incorporate a hydrophobic compound benzophenone (BP) into core–shell nanoparticles (NPs) and to study its release. The core of these NPs is based on polylactic acid (PLA) and serves as a nanocontainer to accommodate BP. The shell is constituted of a β-cyclodextrin polymer (Poly-β-CD) which ensures the control of BP release through non-covalent host–guest interactions. Studies were focused on the preparation, physico-chemical analysis of the BP-loaded NPs and on the elucidation of the release mechanisms. The main features which are the slow kinetics, the dilution-induced release and the total release of encapsulated BP are in good agreement with a mechanism mainly controlled by diffusion of BP and by its binding with the β-CDs cavities present at the surface of NPs.