Bimolecular Compounds Based on Natural Metabolites

New alkaloid-containing derivatives of the sesquiterpene lactones arglabin, grosshemin, 3,4 β -epoxyarglabin, argolide, and parthenolide were prepared for the first time. Their structures were studied using PMR, 13 C NMR, and mass spectra and an X-ray crystal structure analysis. Chemo- and regiosele...

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Published inChemistry of natural compounds Vol. 54; no. 3; pp. 464 - 470
Main Authors Adekenov, S. M., Kishkentaeva, A. S., Shaimerdenova, Zh. R., Atazhanova, G. A.
Format Journal Article
LanguageEnglish
Published New York Springer US 01.05.2018
Springer Nature
Springer
Springer Nature B.V
Subjects
Alkaloids
Chemical synthesis
Chemistry
Chemistry, Medicinal
Chemistry, Organic
Crystal structure
Lactones
Life Sciences & Biomedicine
Mass spectra
Medicine
Metabolites
NMR
Nuclear magnetic resonance
Organic Chemistry
Pharmacology & Pharmacy
Pharmacy
Physical Sciences
Plant Sciences
Science & Technology
Structural analysis
Toxicity
C NMR spectroscopy
PMR and
XSA
mass spectrometry
sesquiterpene lactones
alkaloid-containing derivatives
cytotoxicity
anthelmintic and hepatoprotective activity
PMR and C-13 NMR spectroscopy
CRYSTAL-STRUCTURE
SESQUITERPENE LACTONE
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Summary:New alkaloid-containing derivatives of the sesquiterpene lactones arglabin, grosshemin, 3,4 β -epoxyarglabin, argolide, and parthenolide were prepared for the first time. Their structures were studied using PMR, 13 C NMR, and mass spectra and an X-ray crystal structure analysis. Chemo- and regioselective reactions of the sesquiterpene lactones and alkaloids were observed. The synthesized compounds exhibited anthelmintic and hepatoprotective activity and cytotoxicity.
ISSN:0009-3130
1573-8388
DOI:10.1007/s10600-018-2380-5