Runx2 induces bone osteolysis by transcriptional suppression of TSSC1
•Overexpression of TSSC1 inhibits breast cancer metastasis.•Runx2 transcriptionally down-regulated TSSC1 expression.•Runx2 promotes breast cancer metastasis by down-regulation of TSSC1.•Runx2 mediates breast cancer-induced osteolytic bone disease in a TSSC-dependent manner. Advanced breast cancers f...
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Published in | Biochemical and biophysical research communications Vol. 438; no. 4; pp. 635 - 639 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
06.09.2013
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Subjects | |
Online Access | Get full text |
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Summary: | •Overexpression of TSSC1 inhibits breast cancer metastasis.•Runx2 transcriptionally down-regulated TSSC1 expression.•Runx2 promotes breast cancer metastasis by down-regulation of TSSC1.•Runx2 mediates breast cancer-induced osteolytic bone disease in a TSSC-dependent manner.
Advanced breast cancers frequently metastasize to bone, resulting in osteolytic lesions, however, the underlying mechanisms are poorly understood. Runx2, a bone-specific transcriptional factor, is abnormally expressed in highly metastatic breast cancer cells. Here, we found that TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2. Furthermore, overexpression of Runx2 induces bone osteolysis in a TSSC1-dependent manner. Our results may provide a strategy for the treatment of breast cancer and the prevention of skeletal metastasis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0006-291X 1090-2104 |
DOI: | 10.1016/j.bbrc.2013.07.131 |