6,6′-Bis(2-hydroxyphenyl)-2,2′-bipyridine manganese(III) complexes: A novel series of superoxide dismutase and catalase mimetics

• Published in: Bioorganic & medicinal chemistry letters Vol. 11; no. 11; pp. 1367 - 1370
• Main Authors: Giblin, Gerard M.P, Box, Philip C, Campbell, Ian B, Hancock, Ashley P, Roomans, Susan, Mills, Gary I, Molloy, Christopher, Tranter, George E, Walker, Ann L, Doctrow, Susan R, Huffman, Karl, Malfroy, Bernard
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 04.06.2001; Elsevier
• Subjects: Antioxidants - chemical synthesis; Antioxidants - chemistry; Antioxidants - pharmacology; Biological and medical sciences; Catalase - metabolism; Chemistry; Coordination compounds; Exact sciences and technology; General and cellular metabolism. Vitamins; Hydrogen Peroxide - metabolism; Inorganic chemistry and origins of life; Manganese Compounds - chemical synthesis; Manganese Compounds - chemistry; Manganese Compounds - pharmacology; Medical sciences; Organometallic Compounds - chemical synthesis; Organometallic Compounds - chemistry; Organometallic Compounds - pharmacology; Pharmacology. Drug treatments; Preparations and properties; Salicylates; Structure-Activity Relationship; Superoxide Dismutase - metabolism; Superoxides - metabolism; Phenolate; Enzyme; Organic ligand; Aryloxy complex; Superoxide dismutase; Transition metal Complexes; Acetate; Trivalent metal Complexes; Antioxidant; Pyridine derivatives; Peroxidases; Catalase; Structure activity relation; Biomimetic compound; Manganese III Complexes; Oxidoreductases; Chemical synthesis
• ISSN: 0960-894X; 1464-3405
• DOI: 10.1016/S0960-894X(01)00217-7

A series of novel manganese(III) complexes is described based on a 6,6′-bis(2-hydroxyphenyl)-2,2′-bipyridine template. These complexes show superoxide dismutase and catalase activity. The effect of the aromatic substitution pattern on the SAR is described. A series of novel manganese(III) complexes are described based on a 6,6′-bis(2-hydroxyphenyl)–2,2′-bipyridine template. These complexes show superoxide dismutase and catalase activity. The effect of aromatic substitution pattern on SAR is described.