A second case of hexasomy 8 in myelodysplastic syndrome

Tetrasomy 8 is a rare form of acquired aneuploidy found exclusively in the myeloid leukemias. Hexasomy 8 is even rarer: only one case has been reported, thus far. We describe here the second case of hexasomy 8 as the sole abnormality in an elderly female patient with myelodysplastic syndrome (MDS).

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Bibliographic Details
Published inCancer genetics and cytogenetics Vol. 99; no. 1; pp. 68 - 72
Main Authors Beverstock, Geoffrey C., Wessels, Hans W., Mollebanger, Paul, den Ottolander, Gerard J., Gottlieb, David J.
Format Journal Article
LanguageEnglish
Published New York, NY Elsevier Inc 01.11.1997
Elsevier Science
Subjects
Aged
Aneuploidy
Biological and medical sciences
Bone Marrow - physiology
Chromosomes, Human, Pair 8
Female
Hematologic and hematopoietic diseases
Humans
In Situ Hybridization, Fluorescence
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Myelodysplastic Syndromes - genetics
Myelodysplastic Syndromes - therapy
Chromosomal aberration
Human
Family study
Aneuploidy
Malignant hemopathy
Sibling
Chromosome C8
Myelodysplastic syndrome
Case study
Supernumerary chromosome
Cytogenetics
Genetics
Mosaicism
Elderly
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Summary:Tetrasomy 8 is a rare form of acquired aneuploidy found exclusively in the myeloid leukemias. Hexasomy 8 is even rarer: only one case has been reported, thus far. We describe here the second case of hexasomy 8 as the sole abnormality in an elderly female patient with myelodysplastic syndrome (MDS).
Bibliography:ObjectType-Case Study-3
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ObjectType-Feature-5
ObjectType-Report-2
ObjectType-Article-4
ISSN:0165-4608
1873-4456
DOI:10.1016/S0165-4608(96)00441-4