Acid-base interactions with noradrenaline-induced contractile response of the rabbit isolated aorta

The effect of acidosis and alkalosis on vascular smooth muscle contractions evoked by noradrenaline was studied. Helical strips of rabbit aorta were mounted for isometric tension recording. Acidosis (pH 7.24-6.51) was obtained by either increasing the PCO2 (hypercapnic) and/or lowering the HCO3-conc...

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Published inAnesthesiology (Philadelphia) Vol. 60; no. 5; pp. 400 - 404
Main Authors STOKKE, D. B, ANDERSEN, P. K, BRINKLØV, M. M, NEDERGAARD, O. A, HOLE, P, RASMUSSEN, N. J
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott 01.05.1984
Subjects
Acid-Base Equilibrium
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
Aorta, Thoracic - physiology
Biological and medical sciences
Carbon Dioxide - analysis
Culture Media
Dose-Response Relationship, Drug
Emergency and intensive care: injuries, diseases due to physical agents. Diving. Drowning. Disaster medicine
Emergency and intensive care: metabolism and nutrition disorders. Enteral and parenteral nutrition
Hydrogen-Ion Concentration
In Vitro Techniques
Intensive care medicine
Male
Medical sciences
Muscle Contraction
Muscle, Smooth, Vascular - physiology
Norepinephrine - pharmacology
Norepinephrine - physiology
Oxygen - analysis
Partial Pressure
Rabbits
Tensile Strength
Vertebrata
Experimental disease
Mammalia
Metabolic alkalosis
Rabbit
Aorta
Norepinephrine
Lagomorpha
Metabolic acidosis
Resuscitation
Sympathic nervous system
Isolated organ
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Summary:The effect of acidosis and alkalosis on vascular smooth muscle contractions evoked by noradrenaline was studied. Helical strips of rabbit aorta were mounted for isometric tension recording. Acidosis (pH 7.24-6.51) was obtained by either increasing the PCO2 (hypercapnic) and/or lowering the HCO3-concentration (hypobicarbonatic). Acidosis shifted the noradrenaline concentration-response curve to the right in a competitive manner. The maximal developed tension was unchanged at pH 7.24-6.90 and decreased by 30% at pH 6.51. Alkalosis (pH 7.61-8.04) did not alter noradrenaline-evoked contractions. The results suggest that hydrogen ions during acidosis (pH less than 7.40) but not during alkalosis (pH greater than 7.40) exert alpha-adrenoceptor blocking properties.
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ISSN:0003-3022
1528-1175
DOI:10.1097/00000542-198405000-00002