Estrogen Receptor β: Re-evaluation of Estrogen and Antiestrogen Signaling

Estrogen is of vital importance for the development and control of reproductive functions. Until recently, estrogen was believed to regulate complex programs of gene expression by binding to an unique nuclear receptor belonging to the superfamily of ligand-dependent transcription factors. However, t...

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Bibliographic Details
Published inSteroids Vol. 63; no. 5; pp. 335 - 339
Main Authors Giguère, Vincent, Tremblay, André., Tremblay, Gilles B.
Format Journal Article Conference Proceeding
LanguageEnglish
Published New York, NY Elsevier Inc 01.05.1998
Elsevier Science
Subjects
Animals
antiestrogens
Biological and medical sciences
Cell receptors
Cell structures and functions
Estrogen Antagonists - metabolism
Estrogen Receptor beta
Estrogens - metabolism
Fundamental and applied biological sciences. Psychology
Hormone receptors. Growth factor receptors. Cytokine receptors. Prostaglandin receptors
Mice
Molecular and cellular biology
nuclear receptors
receptor coregulator
Receptors, Estrogen - metabolism
Signal Transduction
nuclear receptors
receptor coregulator
antiestrogens
Signal transduction
Nuclear receptor
Regulation(control)
Estrogen
Review
Sex steroid hormone
Ovarian hormone
Hormonal receptor
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Summary:Estrogen is of vital importance for the development and control of reproductive functions. Until recently, estrogen was believed to regulate complex programs of gene expression by binding to an unique nuclear receptor belonging to the superfamily of ligand-dependent transcription factors. However, the identification of a second estrogen receptor, referred to as ERβ, is leading to a re-evaluation of estrogen signaling and physiology.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0039-128X
1878-5867
DOI:10.1016/S0039-128X(98)00024-5