Assessment of parathyroid autotransplantation for preservation of parathyroid function after total thyroidectomy

• Published in: Head & neck Vol. 25; no. 10; pp. 799 - 807
• Main Authors: El-Sharaky, Magdy I., Kahalil, Mohamed R., Sharaky, Ola, Sakr, Mahmoud F., Fadaly, Geylan A., El-Hammadi, Habashi A., Moussa, Mohamed M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.10.2003; John Wiley & Sons
• Subjects: Adult; Aged; autotransplantation; Biological and medical sciences; Endocrinopathies; Female; Follow-Up Studies; Humans; hypocalcemia; Hypocalcemia - etiology; Hypocalcemia - prevention & control; hypoparathyroidism; Hypoparathyroidism - etiology; Hypoparathyroidism - prevention & control; Hypoparathyroidism - surgery; Male; Medical sciences; Microscopy, Electron; Middle Aged; Non tumoral diseases. Target tissue resistance. Benign neoplasms; parathyroid; Parathyroid Glands - transplantation; parathyroid hormone; Prospective Studies; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of endocrine glands; Thyroid. Thyroid axis (diseases); thyroidectomy; Thyroidectomy - adverse effects; Thyroidectomy - methods; Transplantation, Autologous; Endocrinopathy; Human; Postoperative; parathyroid hormone; Hydroelectrolytic balance disorder; Prognosis; Preservation; Thyroid diseases; Transplantation; parathyroid; Inorganic element; Thyroidectomy; Autotransplantation; Prospective; Prevention; Metabolic disorder; Treatment; Parathyroid diseases; Surgery; Hypoparathyroidism; Total; Complication; Parathyroid glands; Hypocalcemia
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/hed.10278

Background. Hypoparathyroidism with permanent hypocalcemia is a well‐recognized complication after thyroid surgery. Aim. This study was conducted to assess the role of immediate parathyroid autotransplantation in the preservation of parathyroid function after total thyroidectomy. Patients and Methods. Twenty‐eight patients had autotransplantation of parathyroid glands resected or devascularized during total thyroidectomy. Data were collected prospectively regarding demographics, indication for surgery, operative procedure, pathologic diagnosis, number of glands transplanted, and subsequent course. Thyroid nodules were evaluated by ultrasonography, radionuclide scanning, and/or fine‐needle aspiration cytology. All patients had serum ionized calcium, phosphorus, and intact parathyroid hormone (PTH) levels measured preoperatively and monitored regularly postoperatively for a period of 14 weeks and again at 6 months after operation. Patients were categorized into three groups according to the number of glands transplanted: one (group 1, n = 6), two (group 2, n = 14), or three glands (group 3, n = 8). In three other volunteers, one parathyroid gland was transplanted in the brachioradialis and subjected to electron microscopy 1, 2, and 4 weeks after transplantation. Results. Total thyroidectomy was performed for malignant disease in 16 patients (57.1%) and for benign disease in 12 (42.9%) patients. All patients reverted to asymptomatic normocalcemia without the need for any medications within 4 to 14 weeks. Normal levels of serum markers were regained slower when one gland was transplanted compared with two or three glands (P < .01). Electron microscopic examination showed evidence of ischemic degeneration in the transplanted tissues 1 week postoperatively. Regeneration started by the second week and coincided with normalization of PTH levels. Optimum resting and nearly normal status of parathyroid tissue was achieved by the fourth week. Conclusions. This study showed that active PTH production coincides with regeneration of parathyroid cells and that autotransplantation of at least two resected or devascularized glands during total thyroidectomy nearly eliminates permanent postoperative hypoparathyroidism, thus improving the safety of total thyroidectomy performed for malignant or benign disease. © 2003 Wiley Periodicals, Inc. Head and Neck 25: 799–807, 2003