Evaluation of TLR2 and 4 in Chronic Periodontitis

Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection due to oral bacteria. Members of Toll-Like Receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides and activate signall...

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Published inJournal of clinical and diagnostic research Vol. 10; no. 6; pp. ZC86 - ZC89
Main Authors Ilango, Paavai, Mahalingam, Arulpari, Parthasarathy, Harinath, Katamreddy, Vineela, Subbareddy, Venkat
Format Journal Article
LanguageEnglish
Published India JCDR Research and Publications (P) Limited 01.06.2016
JCDR Research and Publications Private Limited
Subjects
Dentistry Section
gingival tissues
intercellular signalling
pathogens
transmembrane proteins
Gingival tissues
Transmembrane proteins
Pathogens
Intercellular signalling
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Summary:Periodontal disease is the major cause of adult tooth loss and is commonly characterized by a chronic inflammation caused by infection due to oral bacteria. Members of Toll-Like Receptor (TLR) family recognize conserved microbial structures, such as bacterial lipopolysaccharides and activate signalling pathways that result in immune responses against microbial infections. The aim of the present study was to assess the mRNA expression of Toll-Like Receptor 2 and 4 in tissues with or without chronic periodontitis. Gingival tissue samples were collected from controls (30 subjects with healthy periodontal tissues) and experimental group (30 subjects with chronic periodontitis). Total RNA was extracted and RT-PCR was done for evaluation of TLR-2 and TLR-4. Mann Whitney U-test, Pearson Chi-square Test was used for statistics. The results showed that there is a significant (p-value= 0.004) association between TLR-4 and the experimental group comprising of chronic periodontitis patients in comparison to the insignificant (p-value= 0.085) TLR-2 expression. This study concludes that TLR-2 and TLR-4 expressed in the gingival tissues recognize different bacterial cell wall components thus helping us to associate its potential in diagnosing periodontal disease. Hence, in the future, these scientific findings can pave the way in using TLR as a diagnostic biomarker for periodontal disease.
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ISSN:2249-782X
0973-709X
DOI:10.7860/JCDR/2016/18353.8027