Effects of growth hormone on initial bone formation around dental implants: a dog study

• Published in: Clinical oral implants research Vol. 22; no. 6; pp. 587 - 593
• Main Authors: Calvo-Guirado, José Luis, Mate-Sanchez, Jose, Delgado-Ruiz, Rafael, Ramirez-Fernández, Maria Piedad, Cutando-Soriano, Antonio, Peña, Monica
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2011
• Subjects: Administration, Topical; Alveolar Bone Loss - pathology; Animals; Bicuspid - surgery; bone remodelling; Connective Tissue - drug effects; Connective Tissue - pathology; Connective tissues; Dental Implantation, Endosseous; Dental Implants; Dentistry; Dogs; Feasibility Studies; growth hormone; Growth Hormone - administration & dosage; Growth Hormone - therapeutic use; Male; Mandible - drug effects; Mandible - pathology; Mandible - surgery; Molar - surgery; oral cavity; Osseointegration - drug effects; Osteogenesis - drug effects; Periodontium - drug effects; Periodontium - pathology; Random Allocation; Recombinant Proteins; Time Factors; Tooth Extraction; Tooth Socket - drug effects; Tooth Socket - pathology; Tooth Socket - surgery
• ISSN: 0905-7161; 1600-0501
• DOI: 10.1111/j.1600-0501.2010.02007.x

Objective: The aim of this study was to evaluate the effects of topical application of growth hormone (GH) on the osteointegration of dental implants in dogs at 5 and 8 weeks after surgery. Materials and methods: Mandibular premolars and molars were extracted from 12 Beagle dogs. Four screw implants were placed in each mandible. Before implant placement, 4 IU of GH were applied to the test sites (TS); no treatment was applied to control sites (CS). Morphometric parameters, bone‐to‐implant contact (BIC), peri‐implant connective tissue, interthread bone and newly formed bone were measured. The Student's t‐test for was used for statistical analysis of data obtained. Results: After 5 weeks of treatment, BIC values varied slightly between 34.33 ± 2.35% (CS) and 35.76 ± 2.96% (TS). Interthread bone tissue was 64.08 ± 8.68 at CS and 72.86 ± 2.93 at TS, with statistical significance (P<0.05). Bone neoformation was 72.53 ± 4.54 at the CS and 80.74 ± 1.65 for the GH group, these being statistically significant differences (P<0.05). After 8 weeks, BIC had slightly increased for the GH group (36.47 ± 3.09 vs. 39.61 ± 2.34). Interthread bone was 80.57 ± 2.28 at the CS and 82.58 ± 2.44 at the GH site, which was statistically significant. Bone neoformation was 88.09 ± 1.38 at CS and 91.01 ± 1.52 at TS, showing statistical significance (P<0.05). Conclusion: Topical application of 4 IU of GH like a biomimetic agent at the moment of implant placement has no significant effects on the BIC at 5 and 8 weeks, although bone neoformation and inter‐thread bone values did increase significantly. To cite this article: 
Calvo‐Guirado JL, Mate‐Sanchez J, Delgado‐Ruiz R, Ramirez‐Fernández MP, Cutando‐Soriano A, Peña M. Effects of growth hormone on initial bone formation around dental implants: a dog study
Clin. Oral Impl. Res. 22, 2011; 587–593.
doi: 10.1111/j.1600‐0501.2010.02007.x