Mechanisms of free radical oxidation of unsaturated lipids

The primary producs formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmenta...

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Published inLipids Vol. 30; no. 4; pp. 277 - 290
Main Authors Porter, Ned A., Caldwell, Sarah E., Mills, Karen A.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer‐Verlag 01.04.1995
Subjects
Free Radicals
Lipid Peroxidation - physiology
Molecular Structure
Oxidation-Reduction
Peroxides
Polyenes - chemistry
Stereoisomerism
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Summary:The primary producs formed from the autoxidation of lipids can be understood based upon a mechanism that involves five different reaction types. These reactions are: reaction of a carbon radical and molecular oxygen, atom transfer of a hydrogen from substrate to the chain carrying peroxyl, fragmentation of the chain carrying peroxyl to give oxygen and a carbon radical, rearrangement of the peroxyl, and cyclization of the peroxyl. The mechanisms of these primary reaction steps has been the focus of extensive research over the past fifty years, and the current level of understanding of these transformations is the subject of this review.
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ISSN:0024-4201
1558-9307
DOI:10.1007/BF02536034