Supra-plasma expanders: the future of treating blood loss and anemia without red cell transfusions?

Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolv...

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Bibliographic Details
Published inJournal of infusion nursing Vol. 38; no. 3; p. 217
Main Authors Tsai, Amy G, Vázquez, Beatriz Y Salazar, Hofmann, Axel, Acharya, Seetharama A, Intaglietta, Marcos
Format Journal Article
LanguageEnglish
Published United States 01.05.2015
Subjects
Anemia - therapy
Erythrocyte Transfusion
Hemorrhage - therapy
Humans
Oxygen - blood
Plasma Substitutes - pharmacology
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Summary:Oxygen delivery capacity during profoundly anemic conditions depends on blood's oxygen-carrying capacity and cardiac output. Oxygen-carrying blood substitutes and blood transfusion augment oxygen-carrying capacity, but both have given rise to safety concerns, and their efficacy remains unresolved. Anemia decreases oxygen-carrying capacity and blood viscosity. Present studies show that correcting the decrease of blood viscosity by increasing plasma viscosity with newly developed plasma expanders significantly improves tissue perfusion. These new plasma expanders promote tissue perfusion, increasing oxygen delivery capacity without increasing blood oxygen-carrying capacity, thus treating the effects of anemia while avoiding the transfusion of blood.
ISSN:1539-0667
DOI:10.1097/NAN.0000000000000103